KPNA2 抗体
(Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008].
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Latest Publications for our KPNA2 抗体
: "Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB." in: Journal of virology, Vol. 91, Issue 8, (2017) (PubMed).: "Essential elements for translation: the germline factor Vasa functions broadly in somatic cells." in: Development (Cambridge, England), Vol. 142, Issue 11, pp. 1960-70, (2015) (PubMed).
: "Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation." in: Journal of cell science, Vol. 128, Issue 12, pp. 2287-301, (2015) (PubMed).
: "Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein." in: Journal of molecular biology, Vol. 411, Issue 2, pp. 397-416, (2011) (PubMed).
: "Cutting edge: tubulin ? functions as an adaptor in NFAT-importin ? interaction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 2710-3, (2011) (PubMed).
: "Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta." in: Genes & development, Vol. 23, Issue 21, pp. 2537-50, (2009) (PubMed).
: "Activity-dependent anchoring of importin alpha at the synapse involves regulated binding to the cytoplasmic tail of the NR1-1a subunit of the NMDA receptor." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 50, pp. 15613-20, (2009) (PubMed).
: "Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 14, pp. 7835-40, (2000) (PubMed).
: "Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 6, pp. 2008-11, (1995) (PubMed).
: "Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 14, pp. 6532-6, (1995) (PubMed).
Aliases for KPNA2 抗体
karyopherin subunit alpha 2 (KPNA2) 抗体importin subunit alpha-2 (EDI_246290) 抗体
importin subunit alpha-2 (EDI_335040) 抗体
Importin subunit alpha-2 (ima2) 抗体
karyopherin subunit alpha 2 (Kpna2) 抗体
karyopherin (importin) alpha 2 (Kpna2) 抗体
karyopherin alpha-2 subunit like L homeolog (kpna2.L) 抗体
karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (kpna2) 抗体
2410044B12Rik 抗体
hm:zeh0389 抗体
hm:zeh0389r 抗体
ima2 抗体
importin 抗体
IPOA1 抗体
ipoa1 抗体
kpna2 抗体
PTAC58 抗体
QIP2 抗体
qip2 抗体
RCH1 抗体
Rch1 抗体
rch1 抗体
SRP1alpha 抗体
srp1alpha 抗体
zgc:86945 抗体
zgc:113902 抗体
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