(Kinetochore-Localized Astrin/SPAG5 Binding Protein (KNSTRN))
Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (By similarity).
Tamura, Simon, Nayak, Shenoy, Hiroi, Boilot, Funahashi, Draviam: "A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset." in: Biology open, Vol. 4, Issue 2, pp. 155-69, (2015) (PubMed).
Shrestha, Draviam: "Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK." in: Current biology : CB, Vol. 23, Issue 16, pp. 1514-26, (2013) (PubMed).