KPNA2 产品
(Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))
Categories
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008].
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Featured KPNA2 Categories
KPNA2 抗体
High quality antibodies with extensive validation data.
KPNA2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
KPNA2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KPNA2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (8)
Cat. No.
ABIN5542626
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7156118
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Rat
Application
WB, ELISA, IHC, IF, FACS
Validations
- (4)
Cat. No.
ABIN185157
Quantity
100 μg
Datasheet
Datasheet
Recommended KPNA2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6957267
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968099
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN454324
Quantity
96 tests
Datasheet
Datasheet
Recommended KPNA2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1308916
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308918
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123665
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our KPNA2 Products
: "Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1β-induced matrix metalloproteinase expression in oral cancer." in: Head & neck, Vol. 40, Issue 8, pp. 1719-1733, (2018) (PubMed).: "KPNA2 is a potential diagnostic serum biomarker for epithelial ovarian cancer and correlates with poor prognosis." in: Tumour biology, Vol. 39, Issue 6, pp. 1010428317706289, (2017) (PubMed).
: "Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB." in: Journal of virology, Vol. 91, Issue 8, (2017) (PubMed).
: "Essential elements for translation: the germline factor Vasa functions broadly in somatic cells." in: Development (Cambridge, England), Vol. 142, Issue 11, pp. 1960-70, (2015) (PubMed).
: "Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation." in: Journal of cell science, Vol. 128, Issue 12, pp. 2287-301, (2015) (PubMed).
: "KPNA2 is a promising biomarker candidate for esophageal squamous cell carcinoma and correlates with cell proliferation." in: Oncology reports, Vol. 32, Issue 4, pp. 1631-7, (2014) (PubMed).
: "Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus replication by controlling the nuclear import of M1." in: Journal of virology, Vol. 87, Issue 11, pp. 6182-91, (2013) (PubMed).
: "Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome." in: International journal of cancer. Journal international du cancer, Vol. 128, Issue 10, pp. 2364-72, (2011) (PubMed).
: "Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein." in: Journal of molecular biology, Vol. 411, Issue 2, pp. 397-416, (2011) (PubMed).
: "Cutting edge: tubulin ? functions as an adaptor in NFAT-importin ? interaction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 2710-3, (2011) (PubMed).
Synonyms and alternative names related to KPNA2
karyopherin subunit alpha 2 (KPNA2), importin subunit alpha-2 (EDI_246290), importin subunit alpha-2 (EDI_335040), Importin subunit alpha-2 (ima2), karyopherin subunit alpha 2 (Kpna2), karyopherin (importin) alpha 2 (Kpna2), karyopherin alpha-2 subunit like L homeolog (kpna2.L), karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (kpna2), 2410044B12Rik, hm:zeh0389, hm:zeh0389r, ima2, importin, IPOA1, ipoa1, kpna2, PTAC58, QIP2, qip2, RCH1, Rch1, rch1, SRP1alpha, srp1alpha, zgc:86945, zgc:113902Protein level used designations for KPNA2
- RAG cohort 1
- RAG cohort protein 1
- SRP1-alpha
- importin alpha 1
- importin alpha 2
- importin subunit alpha-1
- importin subunit alpha-2
- importin-alpha-P1
- karyopherin subunit alpha-2
- pendulin
- Importin subunit alpha-2
- karyopherin (importin) alpha 2
- nuclear import protein
- importin alpha P1
- m-importin-alpha-P1
- pore targeting complex 58 kDa subunit
- karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
- karyopherin alpha-2 subunit like L homeolog
- zeh0389
- zeh0389r
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