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- 应用范围
- Inhibition Assay (InhA), Functional Studies (Func)
- 原理
- FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively, has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively.
- 产品特性
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Target: ERK inhibitor
Receptor: ERK1/2 - 纯化方法
- All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
- 纯度
- 98 %
- Formula
- C18H13N7
- Solubility
- 100 mM in DMSO
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Solid
- 储存条件
- -20 °C
- 储存方法
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For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours. - 有效期
- 24 months
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Cdc42 regulates LPS-induced proliferation of primary pulmonary microvascular endothelial cells via ERK pathway." in: Microvascular research, Vol. 109, pp. 45-53, (2016) (PubMed).
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Cdc42 regulates LPS-induced proliferation of primary pulmonary microvascular endothelial cells via ERK pathway." in: Microvascular research, Vol. 109, pp. 45-53, (2016) (PubMed).
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- 背景
- MAPK Signaling
- 分子量
- 327.34 g/mol
- CAS-编号
- 865362-74-9
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