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抗Human HYAL1 抗体:
抗Mouse (Murine) HYAL1 抗体:
抗Rat (Rattus) HYAL1 抗体:
Human Polyclonal HYAL1 Primary Antibody for IHC, IHC (p) - ABIN4320742
Siiskonen, Poukka, Tyynelä-Korhonen, Sironen, Pasonen-Seppänen: Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma. in BMC cancer 2013
Show all 2 Pubmed References
Human Polyclonal HYAL1 Primary Antibody for ELISA, WB - ABIN516762
Panogeorgou, Tserbini, Filou, Vynios, Naxakis, Papadas, Goumas, Mastronikolis: Hyaluronan synthases and hyaluronidases in nasal polyps. in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2016
Human Polyclonal HYAL1 Primary Antibody for WB - ABIN516763
Papakonstantinou, Kouri, Karakiulakis, Klagas, Eickelberg: Increased hyaluronic acid content in idiopathic pulmonary arterial hypertension. in The European respiratory journal 2008
Human Polyclonal HYAL1 Primary Antibody for ELISA - ABIN314303
Daginakatte, Gutmann: Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth. in Human molecular genetics 2007
Data revealed a significant inverse correlation between ERalpha (显示 ESR1 抗体) and HYAL1 gene expression in human breast tumors. HYAL1 was found repressed by estrogen through ERalpha (显示 ESR1 抗体) binding to a consensus response element (ERE) located in the proximal promoter of HYAL1 and flanked by an Sp1 (显示 PSG1 抗体) binding site, required to achieve optimal estrogen repression.
Ureaplasma urealyticum infection may affect the activity of hyaluronidase (显示 HAase 抗体) on spermatozoa
our results suggest that the enzyme HYAL1 plays a role in tumor dissemination and brain-specific (显示 CALY 抗体) colonization, rather than in subsequent metastatic out-growth.
HAS2 (显示 HAS2 抗体) and HAS3 (显示 HAS3 抗体) were the only hyaluronan synthases detected, the expression of which was almost similar in NPs (显示 NPS 抗体) and NM.
The receiver-operating characteristic curve analyses demonstrated that each one had good sensitivity and specificity for distinguishing BC patients from non-BC ones (HYAL1, miR (显示 MLXIP 抗体)-210, miR (显示 MLXIP 抗体)-96, lncRNA-UCA1, 91.5 and ).
Study showed that reduced HYAL1 expression was associated with endometrial carcinoma aggressiveness, which further supported the role of hyaluronan degradation in cancer progression.
Results demonstrated that HYAL1 was C-mannosylated and suggest the possible role of C-mannosylation for secretion and enzymatic activity of HYAL1.
Hyaluronan (HA) interacting proteins RHAMM (显示 HMMR 抗体) and hyaluronidase (显示 HAase 抗体) impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels.
In contrast to the previously described MPS IX patient, our three patients display a phenotype limited to the joints, suggesting that this is the primary manifestation of HYAL1 deficiency.
Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis.
results are consistent with a role for hyaluronan and hyaluronoglucosaminidase 1 and 2 in the development of the microscopic folds of the pig placenta during gestation
the porcine hyaluronidase (显示 HAase 抗体) cluster consisting of genes HYAL1, HYAL2 (显示 HYAL2 抗体) and HYAL3 (显示 HYAL3 抗体) was characterized
This study focuses on the investigation of the digestibility of glycosaminoglycans with different degrees of sulfation by bovine testicular hyaluronidase (显示 HAase 抗体).
It was concluded that: HYAL1 and HYAL2 (显示 HYAL2 抗体) are both needed for tissue HA catabolism; 2) HYAL2 (显示 HYAL2 抗体) is required for high MW HA clearance in lymph nodes and plasma and for HA endocytosis by liver NPCs; and 3) the main role of HYAL1 is HA degradation within liver NPCs.
Findings suggest that HYAL1 contributes to endothelial and glycocalyx dysfunction induced by diabetes. HYAL1 inhibitors could be explored as a new therapeutic approach to prevent vascular complications in diabetes.
HYAL1 is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 (显示 HYAL2 抗体) is essential for the degradation of extracellular HA in all kidney regions
The activity of the processed form of Hyal-1 was largely underestimated.
The knockdown of Hyal-1 results in an 80% decrease of total acid hyaluronidase (显示 HAase 抗体) activity in the mouse liver, confirming that Hyal-1 is a key actor of hyaluronic acid catabolism in this organ.
Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies through HYAL1
both HYAL1 and beta-hexosaminidase (显示 HEXA 抗体) cleave chondroitin sulfate, but it is a preferred substrate for beta-hexosaminidase (显示 HEXA 抗体). These studies provide in vivo evidence to support and extend existing knowledge of GAG breakdown.
Data show that Hyal-1, but not Hyal-3 (显示 HYAL3 抗体),is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin (显示 FST 抗体)/activin (显示 Actbeta 抗体)/Smad3 (显示 SMAD3 抗体) pathway.
Endothelial surface layer degradation by chronic hyaluronidase (显示 HAase 抗体) infusion induces proteinuria in apolipoprotein E (显示 APOE 抗体)-deficient mice
Characterization of the murine hyaluronidase (显示 HAase 抗体) gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 (显示 NAT6 抗体) and Hyal3 (显示 HYAL3 抗体).
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
, lung carcinoma protein 1
, plasma hyaluronidase
, tumor suppressor LUCA-1
, hyaluronidase 1