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GCH1 产品

(GTP Cyclohydrolase 1 (GCH1))

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This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008].

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Featured GCH1 Categories

GCH1 抗体

High quality antibodies with extensive validation data.

GCH1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

GCH1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended GCH1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IP
Validations
  • (11)
  • (6)
Cat. No. ABIN561018
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN7267525
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (3)
Cat. No. ABIN302137
Quantity 100 μg
Datasheet Datasheet

Recommended GCH1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1135670
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1135672
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1135669
Quantity 96 tests
Datasheet Datasheet

Recommended GCH1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1354910
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354912
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3121448
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our GCH1 Products

Jabs, Oelze, Mikhed, Stamm, Kröller-Schön, Welschof, Jansen, Hausding, Kopp, Steven, Schulz, Stasch, Münzel, Daiber: "Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats." in: Vascular pharmacology, Vol. 71, pp. 181-91, (2015) (PubMed).

Barajas-Espinosa, Basye, Jesse, Yan, Quan, Chen: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." in: Free radical biology & medicine, Vol. 74, pp. 188-99, (2014) (PubMed).

Kossmann, Hu, Steven, Schönfelder, Fraccarollo, Mikhed, Brähler, Knorr, Brandt, Karbach, Becker, Oelze, Bauersachs, Widder, Münzel, Daiber, Wenzel: "Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27540-50, (2014) (PubMed).

Pickert, Lim, Weigert, Häussler, Myrczek, Waldner, Labocha, Ferreirós, Geisslinger, Lötsch, Becker, Brüne, Tegeder: "Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages." in: International journal of cancer. Journal international du cancer, Vol. 132, Issue 3, pp. 591-604, (2012) (PubMed).

Oelze, Knorr, Schuhmacher, Heeren, Otto, Schulz, Reifenberg, Wenzel, Münzel, Daiber: "Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency." in: Journal of vascular research, Vol. 48, Issue 4, pp. 275-84, (2011) (PubMed).

Teng, Du, Xu, Bakhutashvili, Eis, Shi, Pritchard, Konduri: "Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 3, pp. L334-45, (2011) (PubMed).

Schuhmacher, Oelze, Bollmann, Kleinert, Otto, Heeren, Steven, Hausding, Knorr, Pautz, Reifenberg, Schulz, Gori, Wenzel, Münzel, Daiber: "Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy." in: Diabetes, Vol. 60, Issue 10, pp. 2608-16, (2011) (PubMed).

Kröller-Schön, Schulz, Wenzel, Kleschyov, Hortmann, Torzewski, Oelze, Renné, Daiber, Münzel: "Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress." in: Basic research in cardiology, Vol. 106, Issue 6, pp. 1147-58, (2011) (PubMed).

Wenzel, Daiber, Oelze, Brandt, Closs, Xu, Thum, Bauersachs, Ertl, Zou, Förstermann, Münzel: "Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus." in: Atherosclerosis, Vol. 198, Issue 1, pp. 65-76, (2008) (PubMed).

Seujange, Eiam-Ong, Tirawatnapong, Eiam-Ong: "Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion." in: American journal of nephrology, Vol. 28, Issue 4, pp. 692-700, (2008) (PubMed).

Synonyms and alternative names related to GCH1

GTP cyclohydrolase 1 (GCH1), GTP cyclohydrolase 1 (Gch1), GTP cyclohydrolase 1 (gch1), GTP cyclohydrolase 1 (Weevi_1190), GTP cyclohydrolase 1 (Halhy_0838), GTP cyclohydrolase 1 (Sinme_1220), GTP cyclohydrolase 1 (Sphch_1077), GTP cyclohydrolase 1-like (LOC100136794), DYT5, DYT5a, DYT14, GCH, Gch, gch1a, GTP-CH, GTP-CH-1, GTPCH, GTPCH1, HPABH4B, MGC89622, wu:fc16b10, zgc:195269

Protein level used designations for GCH1

  • GTP cyclohydrolase I
  • GTP-CH-I
  • dystonia 14
  • guanosine 5'-triphosphate cyclohydrolase I
  • GTP cyclohydrolase 1 (dopa-responsive dystonia)
  • GTP cyclohydrolase 1
  • GTP cyclohydrolase I (form A; N-terminus)
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