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GCH1 抗体

(GTP Cyclohydrolase 1 (GCH1))
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008].
GCH1 抗体  (AA 84-172) GCH1 抗体  (AA 84-172) GCH1 抗体 (AA 84-172) (ABIN561018)

GCH1 适用: 人 IHC (p), IP, ELISA, WB 宿主: 小鼠 Monoclonal 4A12 unconjugated

GCH1 抗体  (AA 1-250) GCH1 抗体  (AA 1-250) GCH1 抗体 (AA 1-250) (ABIN7267525)

GCH1 适用: 人 IF, WB 宿主: 兔 Polyclonal unconjugated

GCH1 抗体  (Internal Region) GCH1 抗体  (Internal Region) GCH1 抗体 (Internal Region) (ABIN302137)

Verified GCH1 适用: 人 ELISA, IHC, WB 宿主: 山羊 Polyclonal unconjugated

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Find GCH1 抗体 for a variety of species such as anti-Human GCH1, anti-Mouse GCH1, anti-Rat GCH1. The species listed below are among those available. Click on a link to go to the corresponding products.

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Popular GCH1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC (p), IP, ELISA, WB
Validations
  • (11)
  • (6)
Cat. No. ABIN561018
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IF, WB
Validations
  • (4)
Cat. No. ABIN7267525
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN302137
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (2)
Cat. No. ABIN7190766
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC (p), WB
Validations
  • (2)
Cat. No. ABIN652021
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application IF, ELISA
Validations
  • (2)
Cat. No. ABIN561020
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IF, WB
Validations
  • (2)
Cat. No. ABIN515982
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application IF, ELISA
Validations
  • (2)
Cat. No. ABIN561019
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (2)
Cat. No. ABIN2437410
Quantity 400 μL
Datasheet Datasheet
Reactivity Mouse
Application ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (1)
Cat. No. ABIN725510
Quantity 100 μL
Datasheet Datasheet

Application WB
Validations
  • (1)
Cat. No. ABIN6746623
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN929286
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN561016
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN561017
Quantity 50 μL
Datasheet Datasheet
Reactivity Cow, Dog, Human, Rabbit, Rat
Application WB
Validations
  • (1)
Cat. No. ABIN2788139
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our GCH1 抗体

Jabs, Oelze, Mikhed, Stamm, Kröller-Schön, Welschof, Jansen, Hausding, Kopp, Steven, Schulz, Stasch, Münzel, Daiber: "Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats." in: Vascular pharmacology, Vol. 71, pp. 181-91, (2015) (PubMed).

Barajas-Espinosa, Basye, Jesse, Yan, Quan, Chen: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." in: Free radical biology & medicine, Vol. 74, pp. 188-99, (2014) (PubMed).

Kossmann, Hu, Steven, Schönfelder, Fraccarollo, Mikhed, Brähler, Knorr, Brandt, Karbach, Becker, Oelze, Bauersachs, Widder, Münzel, Daiber, Wenzel: "Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27540-50, (2014) (PubMed).

Pickert, Lim, Weigert, Häussler, Myrczek, Waldner, Labocha, Ferreirós, Geisslinger, Lötsch, Becker, Brüne, Tegeder: "Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages." in: International journal of cancer. Journal international du cancer, Vol. 132, Issue 3, pp. 591-604, (2012) (PubMed).

Oelze, Knorr, Schuhmacher, Heeren, Otto, Schulz, Reifenberg, Wenzel, Münzel, Daiber: "Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency." in: Journal of vascular research, Vol. 48, Issue 4, pp. 275-84, (2011) (PubMed).

Teng, Du, Xu, Bakhutashvili, Eis, Shi, Pritchard, Konduri: "Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 3, pp. L334-45, (2011) (PubMed).

Schuhmacher, Oelze, Bollmann, Kleinert, Otto, Heeren, Steven, Hausding, Knorr, Pautz, Reifenberg, Schulz, Gori, Wenzel, Münzel, Daiber: "Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy." in: Diabetes, Vol. 60, Issue 10, pp. 2608-16, (2011) (PubMed).

Kröller-Schön, Schulz, Wenzel, Kleschyov, Hortmann, Torzewski, Oelze, Renné, Daiber, Münzel: "Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress." in: Basic research in cardiology, Vol. 106, Issue 6, pp. 1147-58, (2011) (PubMed).

Wenzel, Daiber, Oelze, Brandt, Closs, Xu, Thum, Bauersachs, Ertl, Zou, Förstermann, Münzel: "Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus." in: Atherosclerosis, Vol. 198, Issue 1, pp. 65-76, (2008) (PubMed).

Seujange, Eiam-Ong, Tirawatnapong, Eiam-Ong: "Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion." in: American journal of nephrology, Vol. 28, Issue 4, pp. 692-700, (2008) (PubMed).

Aliases for GCH1 抗体

GTP cyclohydrolase 1 (GCH1) 抗体
GTP cyclohydrolase 1 (Gch1) 抗体
GTP cyclohydrolase 1 (gch1) 抗体
GTP cyclohydrolase 1 (Weevi_1190) 抗体
GTP cyclohydrolase 1 (Halhy_0838) 抗体
GTP cyclohydrolase 1 (Sinme_1220) 抗体
GTP cyclohydrolase 1 (Sphch_1077) 抗体
GTP cyclohydrolase 1-like (LOC100136794) 抗体
DYT5 抗体
DYT5a 抗体
DYT14 抗体
GCH 抗体
Gch 抗体
gch1a 抗体
GTP-CH 抗体
GTP-CH-1 抗体
GTPCH 抗体
GTPCH1 抗体
HPABH4B 抗体
MGC89622 抗体
wu:fc16b10 抗体
zgc:195269 抗体
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