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GCH1 抗体

(GTP Cyclohydrolase 1 (GCH1))
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008].
GCH1 抗体  (AA 84-172) GCH1 抗体  (AA 84-172) GCH1 抗体 (AA 84-172) (ABIN561018)

GCH1 适用: 人 WB, ELISA, IHC (p), IP 宿主: 小鼠 Monoclonal 4A12 unconjugated

GCH1 抗体  (AA 1-250) GCH1 抗体  (AA 1-250) GCH1 抗体 (AA 1-250) (ABIN7267525)

GCH1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

GCH1 抗体  (Internal Region) GCH1 抗体  (Internal Region) GCH1 抗体 (Internal Region) (ABIN302137)

Verified GCH1 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

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Find GCH1 抗体 for a variety of species such as anti-Human GCH1, anti-Mouse GCH1, anti-Rat GCH1. The species listed below are among those available. Click on a link to go to the corresponding products.

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Popular GCH1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IP
Validations
  • (11)
  • (6)
Cat. No. ABIN561018
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN7267525
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (3)
Cat. No. ABIN302137
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7190766
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF
Validations
  • (2)
Cat. No. ABIN561020
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IF
Validations
  • (2)
Cat. No. ABIN561019
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN515982
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
Cat. No. ABIN725510
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN561016
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN561017
Quantity 50 μL
Datasheet Datasheet

Application WB
Validations
  • (1)
Cat. No. ABIN6746623
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
Cat. No. ABIN652021
Quantity 400 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN725512
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IF (cc), IF (p)
Validations
Cat. No. ABIN899919
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IF (cc), IF (p)
Validations
Cat. No. ABIN899918
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our GCH1 抗体

Jabs, Oelze, Mikhed, Stamm, Kröller-Schön, Welschof, Jansen, Hausding, Kopp, Steven, Schulz, Stasch, Münzel, Daiber: "Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats." in: Vascular pharmacology, Vol. 71, pp. 181-91, (2015) (PubMed).

Barajas-Espinosa, Basye, Jesse, Yan, Quan, Chen: "Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from Cd²?-induced apoptosis." in: Free radical biology & medicine, Vol. 74, pp. 188-99, (2014) (PubMed).

Kossmann, Hu, Steven, Schönfelder, Fraccarollo, Mikhed, Brähler, Knorr, Brandt, Karbach, Becker, Oelze, Bauersachs, Widder, Münzel, Daiber, Wenzel: "Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27540-50, (2014) (PubMed).

Pickert, Lim, Weigert, Häussler, Myrczek, Waldner, Labocha, Ferreirós, Geisslinger, Lötsch, Becker, Brüne, Tegeder: "Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages." in: International journal of cancer. Journal international du cancer, Vol. 132, Issue 3, pp. 591-604, (2012) (PubMed).

Oelze, Knorr, Schuhmacher, Heeren, Otto, Schulz, Reifenberg, Wenzel, Münzel, Daiber: "Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency." in: Journal of vascular research, Vol. 48, Issue 4, pp. 275-84, (2011) (PubMed).

Teng, Du, Xu, Bakhutashvili, Eis, Shi, Pritchard, Konduri: "Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 3, pp. L334-45, (2011) (PubMed).

Schuhmacher, Oelze, Bollmann, Kleinert, Otto, Heeren, Steven, Hausding, Knorr, Pautz, Reifenberg, Schulz, Gori, Wenzel, Münzel, Daiber: "Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy." in: Diabetes, Vol. 60, Issue 10, pp. 2608-16, (2011) (PubMed).

Kröller-Schön, Schulz, Wenzel, Kleschyov, Hortmann, Torzewski, Oelze, Renné, Daiber, Münzel: "Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress." in: Basic research in cardiology, Vol. 106, Issue 6, pp. 1147-58, (2011) (PubMed).

Wenzel, Daiber, Oelze, Brandt, Closs, Xu, Thum, Bauersachs, Ertl, Zou, Förstermann, Münzel: "Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus." in: Atherosclerosis, Vol. 198, Issue 1, pp. 65-76, (2008) (PubMed).

Seujange, Eiam-Ong, Tirawatnapong, Eiam-Ong: "Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion." in: American journal of nephrology, Vol. 28, Issue 4, pp. 692-700, (2008) (PubMed).

Aliases for GCH1 抗体

GTP cyclohydrolase 1 (GCH1) 抗体
GTP cyclohydrolase 1 (Gch1) 抗体
GTP cyclohydrolase 1 (gch1) 抗体
GTP cyclohydrolase 1 (Weevi_1190) 抗体
GTP cyclohydrolase 1 (Halhy_0838) 抗体
GTP cyclohydrolase 1 (Sinme_1220) 抗体
GTP cyclohydrolase 1 (Sphch_1077) 抗体
GTP cyclohydrolase 1-like (LOC100136794) 抗体
DYT5 抗体
DYT5a 抗体
DYT14 抗体
GCH 抗体
Gch 抗体
gch1a 抗体
GTP-CH 抗体
GTP-CH-1 抗体
GTPCH 抗体
GTPCH1 抗体
HPABH4B 抗体
MGC89622 抗体
wu:fc16b10 抗体
zgc:195269 抗体
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