GCH1 蛋白
(GTP Cyclohydrolase 1 (GCH1))
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008].
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10 results
GCH1
宿主: 人
宿主: 小麦胚
Recombinant
WB, ELISA, AA, AP
1 image
1 reference
custom-made
GCH1
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
WB, ELISA, SDS
GCH1
宿主: Velvet bean (Mucuna pruriens)
宿主: 酵母菌
Recombinant
> 90 %
ELISA
Latest Publications for our GCH1 蛋白
: "Regulation of tetrahydrobiopterin biosynthesis by shear stress." in: Circulation research, Vol. 101, Issue 8, pp. 830-8, (2007) (PubMed).
Aliases for GCH1 蛋白
GTP cyclohydrolase 1 (GCH1) 蛋白GTP cyclohydrolase 1 (Gch1) 蛋白
GTP cyclohydrolase 1 (gch1) 蛋白
GTP cyclohydrolase 1 (Weevi_1190) 蛋白
GTP cyclohydrolase 1 (Halhy_0838) 蛋白
GTP cyclohydrolase 1 (Sinme_1220) 蛋白
GTP cyclohydrolase 1 (Sphch_1077) 蛋白
GTP cyclohydrolase 1-like (LOC100136794) 蛋白
DYT5 蛋白
DYT5a 蛋白
DYT14 蛋白
GCH 蛋白
Gch 蛋白
gch1a 蛋白
GTP-CH 蛋白
GTP-CH-1 蛋白
GTPCH 蛋白
GTPCH1 蛋白
HPABH4B 蛋白
MGC89622 蛋白
wu:fc16b10 蛋白
zgc:195269 蛋白
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