Fgr 抗体
(Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
Validations
Cat. No.
ABIN1714757
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
ELISA, IHC (p), IHC (fro)
Validations
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Quantity
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Datasheet
Datasheet
Latest Publications for our Fgr 抗体
: "Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells." in: eLife, Vol. 8, (2020) (PubMed).: "Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF-1-induced macrophage migration." in: Journal of leukocyte biology, Vol. 100, Issue 1, pp. 163-75, (2016) (PubMed).
: "LynA regulates an inflammation-sensitive signaling checkpoint in macrophages." in: eLife, Vol. 4, (2016) (PubMed).
: "High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells." in: Molecular cancer research : MCR, Vol. 9, Issue 6, pp. 724-32, (2011) (PubMed).
: "SRC family kinase activity is up-regulated in hormone-refractory prostate cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 10, pp. 3540-9, (2009) (PubMed).
: "Coactivator assembly at the promoter: efficient recruitment of SRC2 is coupled to cooperative DNA binding by the progesterone receptor." in: Biochemistry, Vol. 46, Issue 39, pp. 11023-32, (2007) (PubMed).
: "The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B." in: Immunity, Vol. 22, Issue 2, pp. 235-46, (2005) (PubMed).
: "Inhibition of receptor-dependent urokinase signaling by specific Ser to Glu substitutions." in: Biological chemistry, Vol. 383, Issue 1, pp. 107-13, (2002) (PubMed).
: "Expression of the retinoblastoma protein is regulated in normal human tissues." in: The American journal of pathology, Vol. 144, Issue 3, pp. 500-10, (1994) (PubMed).
: "The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest." in: Cell, Vol. 79, Issue 1, pp. 119-30, (1994) (PubMed).
Aliases for Fgr 抗体
FGR proto-oncogene, Src family tyrosine kinase (FGR) 抗体FGR proto-oncogene, Src family tyrosine kinase (Fgr) 抗体
c-fgr 抗体
c-src2 抗体
p55-Fgr 抗体
p55c-fgr 抗体
p58-Fgr 抗体
p58c-fgr 抗体
SRC2 抗体
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