anti-Insulin Receptor Substrate 1 (IRS1) 抗体产品概述

Full name:: anti-Insulin Receptor Substrate 1 抗体 (IRS1)

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别名:: G972R, HIRS-1, irs-1, IRS1, irs1-a, IRS1IRM, irsu

列出全部抗体	基因	基因ID	UniProt
	IRS1	3667	P35568
	IRS1	16367	P35569
	IRS1	25467	P35570
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Human Polyclonal IRS1 Primary Antibody for IHC - ABIN966417 : Steppan, Wang, Whiteman, Birnbaum, Lazar: Activation of SOCS-3 by resistin. in Molecular and cellular biology 2005 (PubMed)
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Human Monoclonal IRS1 Primary Antibody for ICS - ABIN1177073 : Burks, White: IRS proteins and beta-cell function. in Diabetes 2001 (PubMed)
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Human Monoclonal IRS1 Primary Antibody for ICS - ABIN1177074 : Gual, Le Marchand-Brustel, Tanti: Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. in Biochimie 2005 (PubMed)
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Human IRS1 Primary Antibody for IHC - ABIN966413 : Tuncman, Hirosumi, Solinas, Chang, Karin, Hotamisligil: Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
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Human IRS1 Primary Antibody for IHC - ABIN966415 : Ozes, Akca, Mayo, Gustin, Maehama, Dixon, Donner: A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
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Human Polyclonal IRS1 Primary Antibody for IHC - ABIN966418 : Tzatsos, Kandror: Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. in Molecular and cellular biology 2005 (PubMed)
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Human IRS1 Primary Antibody for IHC - ABIN966414 : Kadowaki: Insights into insulin resistance and type 2 diabetes from knockout mouse models. in The Journal of clinical investigation 2000 (PubMed)
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Human Polyclonal IRS1 Primary Antibody for IF, IHC - ABIN1531876 : Simon-Szabó, Kokas, Mandl, Kéri, Csala: Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. in PLoS ONE 2014 (PubMed)
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Human Polyclonal IRS1 Primary Antibody for IF (p), IHC (p) - ABIN801453 : Ning, Wang, Gao, Mu, Wang, Liu, Zhu, Meng: Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro. in Molecular nutrition & food research 2017 (PubMed)
Human Polyclonal IRS1 Primary Antibody for IF (p), IHC (p) - ABIN749873 : Luo, Yang, Tang, Yao, Kong, He, Zhou: Kaempferol alleviates insulin resistance via hepatic IKK/NF-?B signal in type 2 diabetic rats. in International immunopharmacology 2015 (PubMed)

更多抗Insulin Receptor Substrate 1的相互作用对抗体

Human Insulin Receptor Substrate 1 (IRS1) interaction partners

Acute loss of IRS1/IRS2 or inhibition of IR/IGF (显示 INSR 抗体)1R in KRAS-mutant human NSCLC cells decreases the (显示 IRS2 抗体) uptake and lowers the intracellular levels of amino acids, while enhancing basal autophagy and sensitivity to autophagy and proteasome i (显示 TP53 抗体)nhibitors.
S6K1 (显示 RPS6KB1 抗体)-dependent IRS (显示 IARS 抗体)-1pSer suppresses insulin (显示 INS 抗体) signaling leading to insulin (显示 INS 抗体) resistance, which is frequently observed in AD brains. Notably, miR (显示 MLXIP 抗体)-200b/c transfection of SH-SY5Y cells reduced the levels of IRS (显示 IARS 抗体)-1pSer. This finding indicates that miR (显示 MLXIP 抗体)-200b/c has the potential to alleviate insulin (显示 INS 抗体) resistance via modulation of S6K1 (显示 RPS6KB1 抗体)
Together, miR (显示 MLXIP 抗体)-145 mimics suppress cell proliferation by targeting and inhibiting IRS1 expression to inhibit MAPK/ERK (显示 MAPK1 抗体) signaling pathways.
Data suggest that Y537S/D538G ESR1 (显示 ESR1 抗体) mutant breast cancer cell lines exhibit enhanced proliferation in response to IGF1 (显示 IGF1 抗体)/IGF1R (显示 IGF1R 抗体) signaling; mechanism involves IRS1; here, knockdown of IRS1 attenuates enhanced IGF1 (显示 IGF1 抗体)/IGF1R (显示 IGF1R 抗体) signaling response in ESR1 (显示 ESR1 抗体) mutant cells. (ESR1 (显示 ESR1 抗体) = estrogen receptor 1 (显示 ESR1 抗体); IGF1 (显示 IGF1 抗体) = insulin like growth factor 1 (显示 IGF1 抗体); IGF1R (显示 IGF1R 抗体) = IGF1 (显示 IGF1 抗体) receptor; IRS1 = insulin receptor substrate 1)
The effect of PF may be associated with its role in inhibiting de novo lipid synthesis and in regulating the ROCK/IRS (显示 IARS 抗体)/Akt (显示 AKT1 抗体) signalling pathways.
Gene expression for insulin receptor substrate 1 (IRS-1), protein kinase B (Akt-2) and glucose transporter 4 (GLUT-4 (显示 SLC2A4 抗体)) genes were evaluated by real time PCR.
Reduced insulin receptor substrate-1 (IRS-1) staining in lung adenocarcinoma tissue microarray displayed a significant survival disadvantage, especially within the Kirsten rat sarcoma viral oncogene (显示 RAB1A 抗体) homolog (KRAS) mutant subgroup.
This study examined the normal regional brain expression of IRS-1 and found a significant correlation with the volumetric associated with regional atrophy in Alzheimer's disease.
Data show that MIR126 induces autophagic flux in malignant mesothelioma (MM) cells by downregulating insulin receptor substrate-1 (IRS1) and disrupting the IRS1 signaling pathway.
IRS1/beta-Catenin (显示 CTNNB1 抗体) Axis Is Activated and Induces MYC (显示 MYC 抗体) Expression in Acute Lymphoblastic Leukemia Cells

Mouse (Murine) Insulin Receptor Substrate 1 (IRS1) interaction partners

Lung-specific dual ablation of insulin receptor (显示 INSR 抗体) substrates 1/2 (succumb to tumor burdenIrs1/Irs2 (显示 IRS2 抗体)) strongly suppresses tumor initiation and dramatically extends the survival of a mouse model of lung cancer with Kras activation and p53 (显示 TP53 抗体) loss. Mice with Irs1/Irs2 loss eventually.
Noise exposure led to enhanced JNK (显示 MAPK8 抗体) phosphorylation and IRS1 serine phosphorylation as well as reduced Akt (显示 AKT1 抗体) phosphorylation in skeletal muscles in response to exogenous insulin (显示 INS 抗体) stimulation.
The data, therefore, suggest that 1,25(OH)2D3 increases glucose consumption by inducing SIRT1 (显示 SIRT1 抗体) activation, which in turn increases IRS1 phosphorylation and GLUT4 (显示 SLC2A4 抗体) translocation in myotubes.
Results show that lack of IRS1 prevents beta-cell apoptosis induced by ER stress, and promotes XBP-1 (显示 XBP1 抗体) instability secondary to proteasomal degradation.
Using two long-lived IIS models, namely Drosophila lacking three insulin (显示 INS 抗体)-like peptides (dilp2 (显示 FLNA 抗体)-3,5(-/-)) and mice lacking insulin receptor substrate 1 (Irs1(-/-)), and two independent translation assays, polysome profiling and radiolabeled amino acid incorporation, we show that reduced IIS lowers translation in these organisms
findings suggest that up-regulation of miR (显示 MLXIP 抗体)-222 followed by reduction in IRS-1 expression may be a viable mechanism of insulin (显示 INS 抗体) resistance in the liver
These results demonstrate the cooperative interaction between RPTPbeta (显示 PTPRZ1 抗体) and the IGF-I receptor (显示 IGF1R 抗体) leading to a coordinated series of signaling events that are required for osteoblast differentiation. Our findings emphasize the important role IRS-1 plays in modulating these signaling events and confirm its essential role in facilitating osteoblast differentiation
EGCG significantly ameliorated insulin (显示 INS 抗体) resistance and cognitive disorder by up-regulating the insulin receptor substrate-1 (IRS-1)/AKT (显示 AKT1 抗体) and ERK (显示 EPHB2 抗体)/cAMP response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF (显示 BDNF 抗体)) signaling pathways.
Pit1 (显示 POU1F1 抗体) deletion inhibited USP7 (显示 USP7 抗体)/IRS1 dissociation upon insulin (显示 INS 抗体) stimulation.
TSH improves insulin (显示 INS 抗体) sensitivity in skeletal muscle by increasing Irs1 gene expression.

Rabbit Insulin Receptor Substrate 1 (IRS1) interaction partners

IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (显示 FTO 抗体) genes regulates body weight in rabbits.

Pig (Porcine) Insulin Receptor Substrate 1 (IRS1) interaction partners

miR (显示 MYLIP 抗体)-146a-5p targets porcine insulin receptor (显示 INSR 抗体) and could inhibit its protein expression.
TBC1D4 (显示 TBC1D4 抗体), insulin receptor (显示 INSR 抗体) and GLUT4 (显示 SLC2A4 抗体) showed altered expression in some tissues in pre-diabetic pigs.
Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.

Xenopus laevis Insulin Receptor Substrate 1 (IRS1) interaction partners

Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (显示 PAX6 抗体) and a decreased cell proliferation.

Insulin Receptor Substrate 1 (IRS1) 抗原简介

Antigen Summary

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Alternative names and synonyms associated with Insulin Receptor Substrate 1 (IRS1)

insulin receptor substrate 1 (IRS1) 抗体
insulin receptor substrate 1 (Irs1) 抗体
insulin receptor substrate 2 (irs2) 抗体
insulin receptor substrate 1 S homeolog (irs1.S) 抗体

G972R 抗体
HIRS-1 抗体
irs-1 抗体
IRS1 抗体
irs1-a 抗体
IRS1IRM 抗体
irsu 抗体

Protein level used designations for IRS1

IRS-1 , pp185 , insulin receptor substrate 1 , XIRS-L , insulin receptor substrate 1-A , xIRS-1-A

GENE ID	SPECIES
3667	Homo sapiens
16367	Mus musculus
25467	Rattus norvegicus
394823	Xenopus (Silurana) tropicalis
459985	Pan troglodytes
486148	Canis lupus familiaris
538598	Bos taurus
100271862	Felis catus
100339981	Oryctolagus cuniculus
100607873	Nomascus leucogenys
100512686	Sus scrofa
100716939	Cavia porcellus
101102293	Ovis aries
399299	Xenopus laevis
101749888	Gallus gallus

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