IRS1 抗体 (AA 1041-1242)
(1 reference)-
- 抗原 See all IRS1 抗体
- IRS1 (Insulin Receptor Substrate 1 (IRS1))
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抗原表位
- AA 1041-1242
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IRS1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- Rabbit IgG polyclonal antibody for Insulin receptor substrate 1(IRS1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
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Rabbit IgG polyclonal antibody for Insulin receptor substrate 1(IRS1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: insulin receptor substrate 1
Protein Name: Insulin receptor substrate 1 - 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human IRS1 recombinant protein (Position: S1041-Q1242). Human IRS1 shares 78% and 80% amino acid (aa) sequences identity with mouse and rat IRS1, respectively.
- 亚型
- IgG
- Top Product
- Discover our top product IRS1 Primary Antibody
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anti-Insulin Receptor Substrate 1 (IRS1) (pSer636) antibody
IRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 1 (IRS1) (pSer639) antibodyIRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 1 (IRS1) (pSer312) antibodyIRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 1 (IRS1) (pSer307) antibodyIRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 1 (IRS1) (AA 106-122), (N-Term) antibodyIRS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 1 (IRS1) (pSer636) antibodyIRS1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 1 (IRS1) (Ser312) antibodyIRS1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 1 (IRS1) (pSer312) antibodyIRS1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, DB 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 1 (IRS1) (pTyr612) antibodyIRS1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, DB 宿主: 兔 Polyclonal unconjugated
anti-Insulin Receptor Substrate 1 (IRS1) (AA 274-323), (pSer307) antibodyIRS1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for IRS1 is approximately 0.25 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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: "MicroRNA-139-5p Suppresses 3T3-L1 Preadipocyte Differentiation Through Notch and IRS1/PI3K/Akt Insulin Signaling Pathways." in: Journal of cellular biochemistry, Vol. 116, Issue 7, pp. 1195-204, (2015) (PubMed).
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: "MicroRNA-139-5p Suppresses 3T3-L1 Preadipocyte Differentiation Through Notch and IRS1/PI3K/Akt Insulin Signaling Pathways." in: Journal of cellular biochemistry, Vol. 116, Issue 7, pp. 1195-204, (2015) (PubMed).
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- 抗原
- IRS1 (Insulin Receptor Substrate 1 (IRS1))
- 别名
- IRS1 (IRS1 产品)
- 别名
- HIRS-1 antibody, G972R antibody, IRS-1 antibody, IRS1IRM antibody, irs1 antibody, irsu antibody, IRS1 antibody, irs-1 antibody, irs1-a antibody, insulin receptor substrate 1 antibody, insulin receptor substrate 2 antibody, insulin receptor substrate 1 S homeolog antibody, IRS1 antibody, Irs1 antibody, irs2 antibody, irs1.S antibody
- 背景
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Insulin receptor substrate 1(IRS-1) is a signalling adapter protein that in humans is encoded by the IRS-1 gene. It is mapped to 2q36.3. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1(IGF-1) receptors to intracellular pathways PI3K/Akt and Erk MAP kinase pathways. IRS1 also has important biological function for both metabolic and mitogenic(growth promoting) pathways. In addition to those, IRS1 is a key regulator of PI3K within malignant cells.
Synonyms: HIRS 1 antibody|HIRS1 antibody|Insulin Receptor Substrate 1 antibody|IRS 1 antibody|IRS-1 antibody|IRS1 antibody|IRS1_HUMAN antibody|OTTHUMP00000164234 antibody - 基因ID
- 3667
- UniProt
- P35568
- 途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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