ErbB2/Her2 (Trastuzumab Biosimilar) 抗体
(ErbB2/Her2 (Trastuzumab Biosimilar))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
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Recommended ErbB2/Her2 (Trastuzumab Biosimilar) 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, ELISA, IHC
Validations
- (1)
Cat. No.
ABIN5668227
Quantity
200 μg
Datasheet
Datasheet
Reactivity
Human
Application
FACS, ELISA, IHC
Validations
- (1)
Cat. No.
ABIN5668226
Quantity
200 μg
Datasheet
Datasheet
Reactivity
Human
Application
FACS, in vivo
Validations
Cat. No.
ABIN7200659
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ErbB2/Her2 (Trastuzumab Biosimilar) Products
: "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer." in: Journal of translational medicine, Vol. 17, Issue 1, pp. 201, (2020) (PubMed).Synonyms and alternative names related to ErbB2/Her2 (Trastuzumab Biosimilar)
erb-b2 receptor tyrosine kinase 2 (ERBB2), CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1Protein level used designations for ErbB2/Her2 (Trastuzumab Biosimilar)
- c-erb B2/neu protein
- herstatin
- metastatic lymph node gene 19 protein
- neuro/glioblastoma derived oncogene homolog
- neuroblastoma/glioblastoma derived oncogene homolog
- p185erbB2
- proto-oncogene Neu
- proto-oncogene c-ErbB-2
- receptor tyrosine-protein kinase erbB-2
- tyrosine kinase-type cell surface receptor HER2
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
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