We are preparing the requested document. Please wait, this may take a while...!
|抗原||Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) 抗体|
|抗原表位||AA 260-310 其他选择|
|适用||人, 小鼠, 大鼠 其他选择|
|标记||This EIF2AK2 antibody is un-conjugated 其他选择|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
EIF2AK2抗体详情EIF2AK2目标详情 使用细节 贮存及处理 References for anti-EIF2AK2 antibody (ABIN687307) 图像
|纯化方法||Purified by Protein A.|
|免疫原||KLH conjugated synthetic peptide derived from human PKR|
EIF2AK2目标详情EIF2AK2抗体详情 使用细节 贮存及处理 References for anti-EIF2AK2 antibody (ABIN687307) 图像 回页首
|别名||Eif2ak2/Pkr (EIF2AK2 Antibody 摘要)|
IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including hepatitis C virus (HCV), hepatitis B virus (HBV), measles virus (MV) and herpes simplex virus 1 (HHV-1). Inhibits viral replication via phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (EIF2S1), this phosphorylation impairs the recycling of EIF2S1 between successive rounds of initiation leading to inhibition of translation which eventually results in shutdown of cellular and viral protein synthesis. Also phosphorylates other substrates including p53/TP53, PPP2R5A, DHX9, ILF3, IRS1 and the HHV-1 viral protein US11. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity and phosphorylates CDK1 at 'Tyr-4' upon DNA damage, facilitating its ubiquitination and proteosomal degradation. Either as an adapter protein and/or via its kinase activity, can regulate various signaling pathways (p38 MAP kinase, NF-kappa-B and insulin signaling pathways) and transcription factors (JUN, STAT1, STAT3, IRF1, ATF3) involved in the expression of genes encoding proinflammatory cytokines and IFNs. Activates the NF-kappa-B pathway via interaction with IKBKB and TRAF family of proteins and activates the p38 MAP kinase pathway via interaction with MAP2K6. Can act as both a positive and negative regulator of the insulin signaling pathway (ISP). Negatively regulates ISP by inducing the inhibitory phosphorylation of insulin receptor substrate 1 (IRS1) at 'Ser-312' and positively regulates ISP via phosphorylation of PPP2R5A which activates FOXO1, which in turn up-regulates the expression of insulin receptor substrate 2 (IRS2).
Subcellular location: Cytoplasm, Nucleus
Synonyms: Interferon-induced, double-stranded RNA-activated protein kinase, Eukaryotic translation initiation factor 2-alpha kinase 2, eIF-2A protein kinase 2, Interferon-inducible RNA-dependent protein kinase, P1/eIF-2A protein kinase, Protein kinase RNA-activated, PKR, Tyrosine-protein kinase EIF2AK2, p68 kinase, EIF2AK2, PRKR
|途径||ER-Nucleus Signaling, Hepatitis C|
使用细节EIF2AK2抗体详情 EIF2AK2目标详情 贮存及处理 References for anti-EIF2AK2 antibody (ABIN687307) 图像 回页首
贮存及处理EIF2AK2抗体详情 EIF2AK2目标详情 使用细节 References for anti-EIF2AK2 antibody (ABIN687307) 图像 回页首
|缓冲液||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|储存方法||Store at -20°C|
References for anti-EIF2AK2 antibody (ABIN687307)EIF2AK2抗体详情 EIF2AK2目标详情 使用细节 贮存及处理 图像 回页首
Lopušná, Benkóczka, Lupták, Matúšková, Lukáčiková, Ovečková, Režuchová: "Murine gammaherpesvirus targets type I IFN receptor but not type III IFN receptor early in infection." in: Cytokine, Vol. 83, pp. 158-70, 2016 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).
图像EIF2AK2抗体详情 EIF2AK2目标详情 使用细节 贮存及处理 References for anti-EIF2AK2 antibody (ABIN687307) 回页首