我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

EIF2AK2 抗体 (pThr446)

Name: EIF2AK2 抗体 (pThr446)
Brand: antibodies-online
SKU: ABIN7138853
Availability: OutOfStock

EIF2AK2 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts from K562 cells using PKR(Phospho-Thr446) Antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).

Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PKR(Phospho-Thr446) Antibody(left) or the same antibody preincubated with blocking peptide(right).

IHC

Immunofluorescence staining of methanol-fixed Hela cells using PKR(Phospho-Thr446) Antibody.

3 images

产品编号 ABIN7138853

发货至: 中国

Datasheet as PDF

抗原 See all EIF2AK2 抗体

EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
抗原表位
45

34

11

7

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pThr446
适用
125

74

49

2

2

1

1

1

1
人
宿主
120

10
兔
Compatible Secondaries
克隆类型
106

24
多克隆
标记
77

5

4

4

4

4

4

4

4

4

3

3

3

3

3

1
This EIF2AK2 antibody is un-conjugated
应用范围
109

45

41

40

36

31

20

17

10

10

8

4

2

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

交叉反应

人, 小鼠

纯化方法

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

免疫原

Peptide sequence around phosphorylation site of threonine 446 (K-R-T(p)-R-S) derived from Human PKR.

亚型

IgG

Top Product

Discover our top product EIF2AK2 Primary Antibody
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 1-100) antibody
EIF2AK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D11 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 1-100) antibody
EIF2AK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1B9 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 329-551) antibody
EIF2AK2 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6H3A10 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 224-502) antibody
EIF2AK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 1-100) antibody
EIF2AK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2C2 unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 11-42) antibody
EIF2AK2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (AA 519-550) antibody
EIF2AK2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (pThr446) antibody
EIF2AK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (pThr451) antibody
EIF2AK2 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) (pThr446), (pThr451) antibody
EIF2AK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

限制

仅限研究用
状态

Liquid

缓冲液

Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

别名

EIF2AK2 (EIF2AK2 产品)

别名

PKR antibody, pkr antibody, EIF2AK2 antibody, DKFZp469K1934 antibody, EIF2AK1 antibody, PRKR antibody, 2310047A08Rik antibody, 4732414G15Rik antibody, AI467567 antibody, AI747578 antibody, Pkr antibody, Prkr antibody, Tik antibody, eukaryotic translation initiation factor 2 alpha kinase 2 antibody, eukaryotic translation initiation factor 2-alpha kinase 2 antibody, EIF2AK2 antibody, eif2ak2 antibody, Eif2ak2 antibody

背景

Background:
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

Abujiang Pataer, et,al. (2002) Cancer Res, 62: 2239.
K. D. Ryman, et,al. (2005) J. Virol, 79: 1487 - 1499.
Susana Guerra, et,al. (2006) J. Biol. Chem, 281: 18734 - 18745.
Aliases: Double stranded RNA activated protein kinase antibody, E2AK2_HUMAN antibody, eIF-2A protein kinase 2 antibody, EIF2AK1 antibody, EIF2AK2 antibody, Eukaryotic translation initiation factor 2 alpha kinase 2 antibody, Eukaryotic translation initiation factor 2-alpha kinase 2 antibody, HGNC:9437 antibody, Interferon induced double stranded RNA activated protein kinase antibody, Interferon inducible elF2 alpha kinase antibody, Interferon inducible RNA dependent protein kinase antibody, Interferon-induced, double-stranded RNA-activated protein kinase antibody, Interferon-inducible RNA-dependent protein kinase antibody, MGC126524 antibody, P1/eIF-2A protein kinase antibody, P1/eIF2A protein kinase antibody, p68 kinase antibody, PKR antibody, PPP1R83 antibody, PRKR antibody, Protein kinase interferon inducible double stranded RNA dependent antibody, Protein kinase RNA activated antibody, Protein kinase RNA-activated antibody, Protein phosphatase 1 regulatory subunit 83 antibody, Serine/threonine protein kinase TIK antibody, Tyrosine protein kinase EIF2AK2 antibody

UniProt

P19525

途径

DNA Damage Repair, ER-Nucleus Signaling, Hepatitis C