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抗Human CBLC 抗体:
抗Rat (Rattus) CBLC 抗体:
抗Mouse (Murine) CBLC 抗体:
Methylmalonic aciduria with homocystinuria cblC is a multisystemic metabolic disease affecting cobalamin metabolism. The presence of retinal alterations in cblC is a common feature and it is reported to develop more frequently and into a more severe form in the early-onset phenotype, suggesting to some extent a correlation with the biochemical phenotype
Data suggest that ubiquitin ligase CBLC controls mostly network organization of the Golgi Apparatus.
Silencing of CBLC causes increased sensitivity to PARP1 (显示 PARP1 抗体) inhibitor olaparib in breast cancer cell line models and that defective homologous recombination (HR) DNA repair is the likely cause.
the effects of two pathogenic missense mutations on the the catalytic activities of the human B12 (显示 NDUFB3 抗体)-processing chaperone CblC
This retrospective multicentre study evaluates clinical, biochemical and genetic findings in 88 cblC patients
The ubiquitin ligase activity of Cbl (显示 CBL 抗体)-c by the direct interaction of the LIM (显示 PDLIM5 抗体) zinc coordinating domain of Hic5 (显示 TGFB1I1 抗体) is demonstrated.
the N terminus of Cbl (显示 CBL 抗体)-c contributes to the binding to the E2 and phosphorylation of Tyr (显示 TYR 抗体)-341 leads to a decrease in affinity and an increase in the E3 activity of Cbl (显示 CBL 抗体)-c
Data demonstrate that two E3 ligases of different classes, CBLC and AIP4 (显示 ITCH 抗体), can interact and cooperate to down-regulate EGFR (显示 EGFR 抗体) signaling.
c-Cbl is a negative regulator of hepatocyte growth factor/receptor tyrosine kinase Met signaling in B cells, mediating ubiquitination and, consequently, proteosomal degradation of Met, with a role in Met-mediated tumorigenesis.
Src (显示 SRC 抗体) is a preferential target of Cbl (显示 CBL 抗体)-c for degradation
bCblC, a bovine B12 (显示 TNFAIP1 抗体) trafficking chaperone, catalyzes elimination of the glutathione ligand from GSCbl by using the reduced form of glutathione (GSH).
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
, Cas-Br-M (murine) ectropic retroviral transforming sequence c
, Cbl proto-oncogene, E3 ubiquitin protein ligase C
, RING finger protein 57
, SH3-binding protein CBL-3
, SH3-binding protein CBL-C
, signal transduction protein CBL-C
, Casitas B-lineage lymphoma c
, E3 ubiquitin-protein ligase CBL-C