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抗Rat (Rattus) 抗体:
Human Polyclonal ERCC5 Primary Antibody for ICC, IF - ABIN261688
Wang, Han, Milum, Wani: Stem cell protein Piwil2 modulates chromatin modifications upon cisplatin treatment. in Mutation research 2011
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This meta-analysis indicated that the XPG gene rs17655 G>C polymorphism was associated with increased overall cancer risk
The polymorphic locus on ERCC5, rs2296147, could reduce the risk of esophageal cancer.
the present study reported on the association between XPG gene polymorphisms and myoma risk. The observed data indicated that SNP rs873601 G>A contributes to uterine leiomyoma susceptibility in a Southern Chinese population.
The aim of the study is to investigate the relation between XPG and XPD gene variants in the DNA repair system and oral squamous cell cancers.
Genome maintenance genes comprised by chronic obstructive pulmonary disease (COPD)-associated bronchial epithelial cell expression patterns were enriched for SNPs with cis-regulatory function, including a putative cis-rSNP in ERCC5 that was associated with COPD risk.
Both rs2296147 and rs1047768 SNPs were found to be associated (P < 0.05) with the risk of breast cancer. XPG rs1047768 was significantly associated with decreased PFS (HR 1.72; 95% CI 1.0-2.8) in breast cancer cases (P = 0.013) which was demonstrated by median time of 26 months for T > C variant. No association was found between XPG rs2296147 polymorphism and survival analysis among breast cancer cases.
The Asp1104His polymorphism of ERCC5 was associated with the risk and 5-year survival rate of colorectal as well as treatment sensitivity to oxaliplatin.
XPG 2228959 C/A polymorphism contributes to protective effect in North Indian lung cancer patients. 2228959 C/A polymorphism might be associated with favorable prognosis in lung cancer risk.
ERCC5 rs17655 polymorphism may be not associated with overall head and neck cancer (HNC) risk. In a subgroup meta-analysis, the results suggest that the ERCC5 rs17655 polymorphism is probably associated with HNC risk in European, but the results should be interpreted with caution for the low number of studies. [meta-analysis]
Xeroderma pigmentosum group G gene rs2094258 polymorphism may be associated with an increased risk of gastric cancer in Southern China (Meta-Analysis)
For XPG rs17655, our results showed that the SNP was not associated with the risk of preeclampsia.
This meta-analysis indicates that the XPG rs751402 polymorphism may be a risk factor for gastric cancer in the Chinese population.
There is a multifarious interaction between the DNA repair gene ERCC5 SNPs (rs2094258 and rs873601) and the metabolic gene GSTP1 rs1695, which may form the basis for various inter-individual susceptibilities to atrophic gastritis in Chinese population.
this meta-analysis shows that XPG gene polymorphisms are associated with lung cancer and gastric cancer
Relevant SNPs in DNA repair (ERCC1 and ERCC5) and apoptosis (MDM2 and TP53) genes might influence the severity of radiation-related side-effects in HNSCC patients. Prospective clinical SNP-based validation studies are needed on these bases
Nine case-control studies involving 3540 cases and 3953 controls were included in the meta-analysis, which revealed that the XPG rs751402 polymorphism is positively associated with GC risk and could be viewed as a risk factor of GC in three genetic models. The XPG gene rs751402 polymorphism is associated with an increased risk of GC in Chinese Han populations. This fi nding should be veri fi ed by larger studies.
In NBEC, T allele at SNP rs2296147 upregulates ERCC5.
XPG gene polymorphism rs751402 was associated with increased susceptibility to gastric cancer in Chinese populations (Meta-Analysis)
Overexpression of human XPG and FEN1 increases genome instability in U2OS cells
This study showed that XPG rs2296147 CT/TT variants conferred significant survival disadvantage in CRC patients in term of PFS.
HIghlighted in this study is the crucial role of XPG's interactions with TFIIH for proper nucleotide excision repair
XPG gene expression can be influenced by an epigenetic mechanism. Restoration of NER activity through XPG gene transfer or treatment with demethylating agents restored sensitivity to nemorubicin.
introduced a point mutation into the XPG gene which inactivates the nuclease catalytic site but leaves the remainder of the protein intact. The mutant mice are hypersensitive to UV irradiation.
Results suggest that the Cockayne syndrome phenotype results from C-terminal truncations in the XPG (xeroderma pigmentosum) gene in mice and humans.
deficiency of exon 15 results in severe growth retardation and short life span
This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.
DNA repair protein complementing XP-G cells
, excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))
, DNA excision repair protein ERCC-5
, XPG-complementing protein
, xeroderma pigmentosum, complementation group G
, DNA repair protein complementing XP-G cells homolog
, DNA-repair protein complementing XP-G cells homolog
, XP-G related factor
, xeroderma pigmentosum group G-complementing protein homolog