Epstein-Barr Virus Nuclear Antigen-3A 抗体
(Epstein-Barr Virus Nuclear Antigen-3A (EBNA-3A))
Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop.