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SAA (显示 SAA1 蛋白), PROZ (显示 PROZ 蛋白), and C4BPB may serve as new potential biomarkers for TB
C4BP (显示 C4BPA 蛋白) is deposited in the diseased aortic valve, coincident with C3d (显示 C3 蛋白) expression.
C4BPB/C4BPA may not confer susceptibility to schizophrenia among Han Chinese
Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells.
crystallographic data on the structure of CD11c (显示 ITGAX 蛋白)/CD18 (显示 ITGB2 蛋白) and prediction of the secondary structure of the C4BP (显示 C4BPA 蛋白) oligomerization domain, we show that epitopes bound by KIM185 in these proteins are unlikely to share any major structural similarity.
C4BP (显示 C4BPA 蛋白) alpha7beta0 subunit [C4BP (显示 C4BPA 蛋白) alpha7beta0 isoform lacking the beta-chain] induces a semimature, tolerogenic state on human monocyte-derived dendritic cells activated by a proinflammatory stimulus.
Since FI requires cofactors for its activity we also investigated the binding of purified cofactors C4BP (显示 C4BPA 蛋白) and FH and found acquisition of both proteins, which retained their activity in FI mediated degradation of C3b and C4b (显示 C4B 蛋白).
Results demonstrate that successful secretion of complement regulatory protein C4b-binding protein beta-chains depends on intracellular complex formation with vitamin K-dependent protein S (显示 PROS1 蛋白), but not on the alpha-chains.
C4BPB/C4BPA (显示 C4BPA 蛋白) is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies.
Localized via protein S to the surface of apoptotic cells, C4BP (显示 C4BPA 蛋白) is able to interact with complement protein C4b (显示 C4B 蛋白), thus retaining its physiological role in regulation of complement on the apoptotic cell surface.
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
complement component 4 binding protein, beta
, complement component 4 binding protein, beta chain
, C4b-binding protein beta chain
, complement component 4-binding protein, beta