CDKN2B 抗体
(Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
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Latest Publications for our CDKN2B 抗体
: "ANRIL inhibits p15(INK4b) through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma." in: Cellular immunology, Vol. 289, Issue 1-2, pp. 91-6, (2014) (PubMed).
: "Phospho-?Np63?-dependent microRNAs modulate chemoresistance of squamous cell carcinoma cells to cisplatin: at the crossroads of cell life and death." in: FEBS letters, Vol. 587, Issue 16, pp. 2536-41, (2013) (PubMed).
: "Hiwi mediated tumorigenesis is associated with DNA hypermethylation." in: PLoS ONE, Vol. 7, Issue 3, pp. e33711, (2012) (PubMed).
: "Strategies to re-express epigenetically silenced p15(INK4b) and p21(WAF1) genes in acute myeloid leukemia." in: Epigenetics, Vol. 5, Issue 8, pp. 696-703, (2010) (PubMed).
: "Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression." in: The Biochemical journal, Vol. 366, Issue Pt 2, pp. 613-21, (2002) (PubMed).
: "Phospho-?Np63?-dependent microRNAs modulate chemoresistance of squamous cell carcinoma cells to cisplatin: at the crossroads of cell life and death." in: FEBS letters, Vol. 587, Issue 16, pp. 2536-41, (2013) (PubMed).
: "Hiwi mediated tumorigenesis is associated with DNA hypermethylation." in: PLoS ONE, Vol. 7, Issue 3, pp. e33711, (2012) (PubMed).
: "Strategies to re-express epigenetically silenced p15(INK4b) and p21(WAF1) genes in acute myeloid leukemia." in: Epigenetics, Vol. 5, Issue 8, pp. 696-703, (2010) (PubMed).
: "Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression." in: The Biochemical journal, Vol. 366, Issue Pt 2, pp. 613-21, (2002) (PubMed).
Aliases for CDKN2B 抗体
cyclin dependent kinase inhibitor 2B (CDKN2B) 抗体Cyclin-dependent kinase 4 inhibitor B (cdn2b) 抗体
cyclin-dependent kinase inhibitor 2B (cdkn2b) 抗体
cyclin-dependent kinase inhibitor 2B L homeolog (cdkn2b.L) 抗体
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (Cdkn2b) 抗体
cyclin-dependent kinase inhibitor 2B (Cdkn2b) 抗体
AV083695 抗体
CDK4I 抗体
cdk4l 抗体
CDKN2A 抗体
ink4b 抗体
INK4B 抗体
INK4b 抗体
mts2 抗体
MTS2 抗体
p14-INK4b 抗体
p15 抗体
P15 抗体
p15(INK4b) 抗体
p15ink4b 抗体
p15INK4b 抗体
tp15 抗体
TP15 抗体
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