(CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2))
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Passemard, El Ghouzzi, Nasser, Verney, Vodjdani, Lacaud, Lebon, Laburthe, Robberecht, Nardelli, Mani, Verloes, Gressens, Lelièvre: "VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling." in: The Journal of clinical investigation, Vol. 121, Issue 8, pp. 3071-87, (2011) (PubMed).
Zyss, Ebrahimi, Gergely: "Casein kinase I delta controls centrosome positioning during T cell activation." in: The Journal of cell biology, Vol. 195, Issue 5, pp. 781-97, (2011) (PubMed).
Lizarraga, Margossian, Harris, Campagna, Han, Blevins, Mudbhary, Barker, Walsh, Fleming: "Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors." in: Development (Cambridge, England), Vol. 137, Issue 11, pp. 1907-17, (2010) (PubMed).
Barr, Kilmartin, Gergely: "CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response." in: The Journal of cell biology, Vol. 189, Issue 1, pp. 23-39, (2010) (PubMed).
Aliases for CDK5RAP2 抗体
CDK5 regulatory subunit associated protein 2 (CDK5RAP2) 抗体 CDK5 regulatory subunit-associated protein 2 (LOC100156240) 抗体 CDK5 regulatory subunit associated protein 2 (cdk5rap2) 抗体 CDK5 regulatory subunit associated protein 2 (Cdk5rap2) 抗体 2900018K03Rik 抗体 an 抗体 C48 抗体 Cep215 抗体 EGFL5 抗体 MCPH3 抗体 mKIAA1633 抗体