CDKN2B 产品
(Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))
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This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
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Recommended CDKN2B 抗体
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Reactivity
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Cat. No.
ABIN1497447
Quantity
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Cat. No.
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Cat. No.
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Recommended CDKN2B 蛋白
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Cat. No.
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Latest Publications for our CDKN2B Products
: "ANRIL inhibits p15(INK4b) through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma." in: Cellular immunology, Vol. 289, Issue 1-2, pp. 91-6, (2014) (PubMed).: "Phospho-?Np63?-dependent microRNAs modulate chemoresistance of squamous cell carcinoma cells to cisplatin: at the crossroads of cell life and death." in: FEBS letters, Vol. 587, Issue 16, pp. 2536-41, (2013) (PubMed).
: "Hiwi mediated tumorigenesis is associated with DNA hypermethylation." in: PLoS ONE, Vol. 7, Issue 3, pp. e33711, (2012) (PubMed).
: "Strategies to re-express epigenetically silenced p15(INK4b) and p21(WAF1) genes in acute myeloid leukemia." in: Epigenetics, Vol. 5, Issue 8, pp. 696-703, (2010) (PubMed).
: "Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression." in: The Biochemical journal, Vol. 366, Issue Pt 2, pp. 613-21, (2002) (PubMed).
Synonyms and alternative names related to CDKN2B
cyclin dependent kinase inhibitor 2B (CDKN2B), Cyclin-dependent kinase 4 inhibitor B (cdn2b), cyclin-dependent kinase inhibitor 2B (cdkn2b), cyclin-dependent kinase inhibitor 2B L homeolog (cdkn2b.L), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (Cdkn2b), cyclin-dependent kinase inhibitor 2B (Cdkn2b), AV083695, CDK4I, cdk4l, CDKN2A, ink4b, INK4B, INK4b, mts2, MTS2, p14-INK4b, p15, P15, p15(INK4b), p15ink4b, p15INK4b, tp15, TP15Protein level used designations for CDKN2B
- Cyclin-dependent kinase 4 inhibitor B
- CDK inhibitory protein
- CDK4B inhibitor
- MTS-2
- cyclin-dependent kinase 4 inhibitor B
- cyclin-dependent kinases 4 and 6 binding protein
- multiple tumor suppressor 2
- p14-INK4b
- p14_CDK inhibitor
- p14_INK4B
- p15 CDK inhibitor
- p15-INK4b
- p15_INK4B
- cyclin-dependent kinase inhibitor p15
- cyclin-dependent kinase inhibitor p15INK4b
- cyclin-dependent kinase inhibitor protein
- Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4)
- cyclin dependant kinase inhibitor
- cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
- cyclin-dependent kinase inhibitor 2B
- cyclin-dependent kinase inhibitor 2B (melanoma, p16, inhibits CDK4)
- p15INK4b tumor suppressor
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