CDK4 产品
(Cyclin-Dependent Kinase 4 (CDK4))
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The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008].
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Featured CDK4 Categories
CDK4 抗体
High quality antibodies with extensive validation data.
CDK4 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
CDK4 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CDK4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, ICC, IHC (p)
Validations
- (2)
- (8)
Cat. No.
ABIN2855529
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (6)
Cat. No.
ABIN6999859
Quantity
20 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
- (6)
Cat. No.
ABIN3187734
Quantity
100 μL
Datasheet
Datasheet
Recommended CDK4 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966166
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966165
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955156
Quantity
96 tests
Datasheet
Datasheet
Recommended CDK4 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1348950
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5570456
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect cells (Sf9)
Validations
- (2)
Cat. No.
ABIN5570012
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our CDK4 Products
: "ASIC1a Inhibitor mambalgin-2 Suppresses the Growth of Leukemia Cells by Cell Cycle Arrest." in: Acta naturae, Vol. 12, Issue 2, pp. 101-116, (2020) (PubMed).: "Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway." in: International journal of molecular medicine, Vol. 44, Issue 5, pp. 1687-1696, (2020) (PubMed).
: "Regulation of miR-34b/c-targeted gene expression program by SUMOylation." in: Nucleic acids research, Vol. 46, Issue 14, pp. 7108-7123, (2019) (PubMed).
: "The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer." in: International journal of oncology, Vol. 51, Issue 5, pp. 1497-1507, (2018) (PubMed).
: "SUMO2 modification of Aurora B and its impact on follicular development and atresia in the mouse ovary." in: International journal of molecular medicine, Vol. 41, Issue 6, pp. 3115-3126, (2018) (PubMed).
: "Proteins of the retinoblastoma pathway, FEN1 and MGMT are novel potential prognostic biomarkers in pancreatic adenocarcinoma." in: Pathology, research and practice, Vol. 214, Issue 6, pp. 840-847, (2018) (PubMed).
: "Immune regulation mechanism of Astragaloside IV on RAW264.7 cells through activating the NF-κB/MAPK signaling pathway." in: International immunopharmacology, Vol. 49, pp. 38-49, (2018) (PubMed).
: "miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression." in: Oncology reports, Vol. 37, Issue 1, pp. 241-248, (2017) (PubMed).
: "Combination of metformin and sorafenib suppresses proliferation and induces autophagy of hepatocellular carcinoma via targeting the mTOR pathway." in: International journal of oncology, Vol. 50, Issue 1, pp. 297-309, (2017) (PubMed).
: "Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins." in: Scientific reports, Vol. 6, pp. 19587, (2017) (PubMed).
Synonyms and alternative names related to CDK4
cyclin-dependent kinase 4 (cdk4), cyclin dependent kinase 4 (CDK4), cyclin-dependent kinase 4 (Cdk4), cyclin dependent kinase 4 (Cdk4), Cyclin-dependent kinase 4 (Cdk4), cyclin-dependent kinase 4 L homeolog (cdk4.L), 8-6, cdk, CDK4, cdk4, CDK4/6, Cdk4/6, cdk4/6, CG5072, CMM3, Crk3, dCdk4, DmCdk4, Dmel\\CG5072, l(2)05428, l(2)0671, l(2)k06503, l(2)s4639, l(2)sh0671, Pk53C, Pk?7, PSK-J3, xcdk4, zgc:153726Protein level used designations for CDK4
- cell division protein kinase 4
- PSK-J3
- cyclin dependent kinase 4
- p34
/cdk4 - serine/threonine kinase
- Cell division protein kinase 4
- CG5072-PA
- CG5072-PB
- CG5072-PC
- Cdk4-PA
- Cdk4-PB
- Cdk4-PC
- Cyclin-dependent kinase 4/6
- cyclin-dependent kinase 4
- protein kinase-like 53C
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