This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008].
Redecker, Heckendorf, Grosch, Mersmann, Hasilik: "Molecular organization of the human cathepsin D gene." in: DNA and cell biology, Vol. 10, Issue 6, pp. 423-31, (1991) (PubMed).
Westley, May: "Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells." in: Nucleic acids research, Vol. 15, Issue 9, pp. 3773-86, (1987) (PubMed).
Faust, Kornfeld, Chirgwin: "Cloning and sequence analysis of cDNA for human cathepsin D." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 15, pp. 4910-4, (1985) (PubMed).
Aliases for Cathepsin D 蛋白
cathepsin D (ctsd) 蛋白 cathepsin D (LOC398557) 蛋白 cathepsin D S homeolog (ctsd.S) 蛋白 cathepsin D (CatD) 蛋白 lysosomal aspartic protease (LOC5567565) 蛋白 cathepsin D (LOC100136761) 蛋白 cathepsin D (CTSD) 蛋白 cathepsin D (Cathd) 蛋白 cathepsin D (ctsD) 蛋白 cathepsin D (catd) 蛋白 cathepsin D (Ctsd) 蛋白 cathepsin D-like (LOC443060) 蛋白 catD 蛋白 CatD 蛋白 Cathd 蛋白 CD 蛋白 CLN10 蛋白 CPSD 蛋白 CTSD 蛋白 DDBDRAFT_0205785 蛋白 DDBDRAFT_0215012 蛋白 DDB_0205785 蛋白 DDB_0215012 蛋白 DKFZp469J0315 蛋白 fb93e11 蛋白 fj17b09 蛋白 LOC398557 蛋白 LOC100136761 蛋白 wu:fb93e11 蛋白 wu:fj17b09 蛋白