Caspase 1 蛋白
(Caspase 1 (CASP1))
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| Caspase 1 Protein (CASP1) (AA 120-404) (His-IF2DI Tag) | 人 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 120-269) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 1-100) (GST tag) | 人 | 小麦胚 |
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| Caspase 1 Protein (CASP1) (AA 1-311) (GST tag) | 人 | 小麦胚 |
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| Caspase 1 Protein (CASP1) (AA 120-296) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 317-404) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 120-297) (His tag) | Pig | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 119-296) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 120-297) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 119-296) (His tag) | 大鼠 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 119-296) | 大鼠 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 120-404) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 120-404) (His tag,GST tag) | 人 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 120-269, partial) (GST tag) | 人 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (Myc-DYKDDDDK Tag) | 人 | HEK-293 Cells |
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| Caspase 1 Protein (CASP1) (AA 119-296) (His tag) | 大鼠 | 大肠杆菌（E. Coli） |
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| Caspase 1 Protein (CASP1) (AA 120-297) (His tag) | Pig | 酵母菌 |
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| Caspase 1 Protein (CASP1) (AA 120-296) (His tag) | Cat | 酵母菌 |
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| Caspase 1 Protein (CASP1) (AA 120-297) (His tag) | 犬 | 酵母菌 |
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Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- SDS (SDS-PAGE: 有验证图片)
- AP (Affinity Purification: 所列应用)
- AA (Antibody Array: 所列应用)
- ELISA (ELISA: 所列应用)
- WB (Western Blotting: 所列应用)
- 宿主
- 人
- 宿主
- 小麦胚
- 蛋白类型
- Recombinant
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- Pig
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 大鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- AcA (Activity Assay: 所列应用)
- CC (Cell Culture: 所列应用)
- 宿主
- 大鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
- 生物活性
- Active
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 80 %
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 所列应用)
3 references - 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- 90 %
Protein
- SDS (SDS-PAGE: 有验证图片)
- WB (Western Blotting: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- WB (Western Blotting: 有验证图片)
- AbP (Antibody Production: 所列应用)
- STD (Standard: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- Pig
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- Cat
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- 犬
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Latest Publications for our Caspase 1 蛋白
: "The β-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP." in: Experimental biology and medicine (Maywood, N.J.), Vol. 239, Issue 4, pp. 454-64, (2014) (PubMed).
: "Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells." in: Carcinogenesis, Vol. 35, Issue 7, pp. 1536-46, (2014) (PubMed).
: "Distinct effects of imperatorin on allergic rhinitis: imperatorin inhibits caspase-1 activity in vivo and in vitro." in: The Journal of pharmacology and experimental therapeutics, Vol. 339, Issue 1, pp. 72-81, (2011) (PubMed).
: "Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome." in: Antimicrobial agents and chemotherapy, Vol. 55, Issue 3, pp. 1028-35, (2011) (PubMed).
: "The capsid proteins of Aleutian mink disease virus activate caspases and are specifically cleaved during infection." in: Journal of virology, Vol. 84, Issue 6, pp. 2687-96, (2010) (PubMed).
: "Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4385-92, (2010) (PubMed).
: "Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34337-47, (2010) (PubMed).
: "Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis." in: Molecular and cellular biology, Vol. 29, Issue 13, pp. 3657-64, (2009) (PubMed).
: "Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 10, pp. 6460-9, (2009) (PubMed).
: "CA-074Me protection against anthrax lethal toxin." in: Infection and immunity, Vol. 77, Issue 10, pp. 4327-36, (2009) (PubMed).
: "Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells." in: Carcinogenesis, Vol. 35, Issue 7, pp. 1536-46, (2014) (PubMed).
: "Distinct effects of imperatorin on allergic rhinitis: imperatorin inhibits caspase-1 activity in vivo and in vitro." in: The Journal of pharmacology and experimental therapeutics, Vol. 339, Issue 1, pp. 72-81, (2011) (PubMed).
: "Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome." in: Antimicrobial agents and chemotherapy, Vol. 55, Issue 3, pp. 1028-35, (2011) (PubMed).
: "The capsid proteins of Aleutian mink disease virus activate caspases and are specifically cleaved during infection." in: Journal of virology, Vol. 84, Issue 6, pp. 2687-96, (2010) (PubMed).
: "Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4385-92, (2010) (PubMed).
: "Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34337-47, (2010) (PubMed).
: "Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis." in: Molecular and cellular biology, Vol. 29, Issue 13, pp. 3657-64, (2009) (PubMed).
: "Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 10, pp. 6460-9, (2009) (PubMed).
: "CA-074Me protection against anthrax lethal toxin." in: Infection and immunity, Vol. 77, Issue 10, pp. 4327-36, (2009) (PubMed).
Aliases for Caspase 1 蛋白
caspase 1 (CASP1) 蛋白caspase 1 (Casp1) 蛋白
caspase 1, apoptosis-related cysteine peptidase (CASP1) 蛋白
caspase 4, apoptosis-related cysteine peptidase (CASP4) 蛋白
Death caspase-1 (Dcp-1) 蛋白
caspase-1 (Caspase1) 蛋白
caspase (LOC5564196) 蛋白
caspase recruitment domain-containing protein 16 (LOC451519) 蛋白
caspase-1 (CASP1) 蛋白
caspase 4 (CASP4) 蛋白
CASP1 蛋白
ccp1 蛋白
CG5370 蛋白
DCP-1 蛋白
dcp-1 蛋白
DCP1 蛋白
Dcp1 蛋白
dcp1 蛋白
Dmel\\CG5370 蛋白
ICE 蛋白
Ice 蛋白
IL1BC 蛋白
Il1bc 蛋白
l(2)01862 蛋白
l(2)02132 蛋白
P45 蛋白
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