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CHEK1 抗体

CHEK1 适用: 人, 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal 2G1D5 unconjugated
产品编号 ABIN969476
发货至: 中国
  • 抗原 See all CHEK1 抗体
    CHEK1 (Checkpoint Kinase 1 (CHEK1))
    适用
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    人, 小鼠
    宿主
    • 224
    • 13
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    • 5
    小鼠
    克隆类型
    • 210
    • 40
    单克隆
    标记
    • 134
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    This CHEK1 antibody is un-conjugated
    应用范围
    • 172
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    • 17
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    • 1
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    Western Blotting (WB), ELISA
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of CHK1 expressed in E. coli.
    克隆位点
    2G1D5
    亚型
    IgG1
    Top Product
    Discover our top product CHEK1 Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified antibody in PBS containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • OConnell, Raleigh, Verkade, Nurse: "Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation." in: The EMBO journal, Vol. 16, Issue 3, pp. 545-54, (1997) (PubMed).

  • 抗原
    CHEK1 (Checkpoint Kinase 1 (CHEK1))
    别名
    CHK1 (CHEK1 产品)
    别名
    An08g10320 antibody, AO090003000441 antibody, CHK1 antibody, chk1 antibody, C85740 antibody, Chk1 antibody, rad27 antibody, id:ibd2720 antibody, zgc:56093 antibody, CHEK1 antibody, checkpoint kinase 1 antibody, serine/threonine-protein kinase chk1 antibody, serine/threonine-protein kinase Chk1 antibody, CAMK/CAMKL/CHK1 protein kinase Chk1 antibody, checkpoint kinase 1 S homeolog antibody, CHEK1 antibody, ANI_1_2436074 antibody, AOR_1_768154 antibody, PTRG_04183 antibody, SJAG_01680 antibody, PAAG_04978 antibody, MCYG_03290 antibody, VDBG_03742 antibody, chek1.S antibody, Chek1 antibody, chek1 antibody
    背景

    Description: CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.

    Aliases: CHEK1

    分子量
    56 kDa
    基因ID
    1111
    HGNC
    1111
    途径
    p53 Pathway, Apoptosis, Cell Division Cycle, DNA Damage Repair
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