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BMPR2 抗体

BMPR2 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 3F6 unconjugated
产品编号 ABIN968988
发货至: 中国
  • 抗原 See all BMPR2 抗体
    BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))
    适用
    • 60
    • 42
    • 15
    • 2
    • 1
    人, 小鼠, 大鼠, 猴
    宿主
    • 55
    • 5
    • 1
    小鼠
    克隆类型
    • 56
    • 5
    单克隆
    标记
    • 33
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This BMPR2 antibody is un-conjugated
    应用范围
    • 48
    • 25
    • 17
    • 15
    • 13
    • 13
    • 10
    • 9
    • 7
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human BMPR2 expressed in E. coli.
    克隆位点
    3F6
    亚型
    IgG1
    Top Product
    Discover our top product BMPR2 Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • Rosenzweig, Morse, Knowles, Chada, Khan, Roberts, McElroy, Juskiw, Mallory, Rich, Diamond, Barst: "Clinical implications of determining BMPR2 mutation status in a large cohort of children and adults with pulmonary arterial hypertension." in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Vol. 27, Issue 6, pp. 668-74, (2008) (PubMed).

    Phillips, Poling, Phillips, Stanton, Austin, Cogan, Wheeler, Yu, Newman, Dietz, Loyd: "Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension." in: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 10, Issue 5, pp. 359-65, (2008) (PubMed).

  • 抗原
    BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))
    别名
    BMPR2 (BMPR2 产品)
    别名
    BMPR-II antibody, BMPR3 antibody, BMR2 antibody, BRK-3 antibody, PPH1 antibody, T-ALK antibody, 2610024H22Rik antibody, AL117858 antibody, AW546137 antibody, BB189135 antibody, BMP-2 antibody, BMPR-2 antibody, BMPRII antibody, Gm20272 antibody, Bmpr-II antibody, bmprii antibody, bone morphogenetic protein receptor type 2 antibody, bone morphogenetic protein receptor, type II b (serine/threonine kinase) antibody, bone morphogenetic protein receptor, type II (serine/threonine kinase) antibody, BMPR2 antibody, bmpr2b antibody, Bmpr2 antibody
    背景

    Description: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. (provided by RefSeq)

    Aliases: BMR2, PPH1, BMPR3, BRK-3, T-ALK, BMPR-II, FLJ41585, FLJ76945, BMPR2

    分子量
    115 kDa
    基因ID
    659
    HGNC
    659
    途径
    Growth Factor Binding
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