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p53 抗体

Cited in 3+ publications. The 兔 多克隆 anti-p53 antibody (ABIN966759) specifically detects p53 in IHC. The antibody is reactive with 人 samples.
产品编号 ABIN966759
发货至: 中国
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中国
北京 101111
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for p53 抗体 (ABIN966759)

抗原

See all p53 (TP53) 抗体
p53 (TP53) (Tumor Protein P53 (TP53))

适用

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宿主

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克隆类型

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多克隆

标记

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This p53 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC)
  • 特异性

    P53 (Ab-315) antibody detects endogenous levels of total p53 protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    免疫原

    The antiserum was produced against synthesized non-phosphopeptide derived from human p53 around the phosphorylation site of serine 315 (S-S-SP-P-Q).
  • 应用备注

    WB: 1:500~1:1000.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    100ug/100ul.

    缓冲液

    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • Merrick, Zhou, Martin, Jeyarajah, Parker, Selkirk, Tomer, Borchers: "Site-specific phosphorylation of human p53 protein determined by mass spectrometry." in: Biochemistry, Vol. 40, Issue 13, pp. 4053-66, (2001) (PubMed).

    Lu, Fisher, Bailey, Levine: "The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro." in: Molecular and cellular biology, Vol. 17, Issue 10, pp. 5923-34, (1997) (PubMed).

    Lohrum, Scheidtmann: "Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes." in: Oncogene, Vol. 13, Issue 12, pp. 2527-39, (1997) (PubMed).

  • 抗原

    p53 (TP53) (Tumor Protein P53 (TP53))

    别名

    P53

    途径

    p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
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