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CHEK1 抗体 (C-Term)

This anti-CHEK1 antibody is a 兔多克隆 antibody detecting CHEK1 in IHC. Suitable for 人.

产品编号 ABIN965880

发货至: 中国

Quick Overview for CHEK1 抗体 (C-Term) (ABIN965880)

抗原

See all CHEK1 抗体

CHEK1 (Checkpoint Kinase 1 (CHEK1))

适用

177
114
62
16
11
8
7
6
6
4
4
3
2
1
1

人

宿主

兔

克隆类型

多克隆

标记

122
11
9
8
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3

This CHEK1 antibody is un-conjugated

应用范围

165
82
54
41
40
33
32
21
16
10
7
6
4
3
3
1
1

Immunohistochemistry (IHC)

Discover our top product CHEK1 Primary Antibody

抗原表位
36

28

19

16

9

7

6

6

5

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term

纯化方法

Purified by antigen-specific affinity chromatography.

免疫原

Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human CHEK1(Serine/threonine-protein kinase Chk1)
anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer301) antibody
CHEK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer296) antibody
CHEK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer286) antibody
CHEK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer345) antibody
CHEK1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (Middle Region) antibody
CHEK1 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 适用: 小鼠, 小鸡 ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 1 (CHEK1) antibody
CHEK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Monoclonal 2F2 unconjugated Recombinant Antibody

anti-Checkpoint Kinase 1 (CHEK1) antibody
CHEK1 适用: 人, 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal 2G1D5 unconjugated

anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
CHEK1 适用: 人 WB, IHC (p), DB 宿主: 兔 Polyclonal RB7845-RB18425 unconjugated

应用备注

ELISA, Western blotting: 1µg/ml for 2hrs.

限制

仅限研究用
状态

Liquid

缓冲液

This antibody is stored in PBS, 50% glycerol

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C
抗原

CHEK1 (Checkpoint Kinase 1 (CHEK1))

别名

CHEK1

背景

CHEK1(Serine/threonine-protein kinase Chk1) involved in cell cycle arrest when dna damage has occurred or when unligated dna is present. CHEK1 binds to and phosphorylates CDC25A, CDC25B and CDC25C. The phosphorylation of CDC25C creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2-Cyclin B complex and prevents mitotic entry. The CHEK1 phosphorylates CDC25C on serine216. Chk1 plays a primary role in the protection of cells from death induced by replication fork stress, whereas p21 mediates through its role in regulating entry into S phase. Chk1 deficiency resulted in a premature onset of mitosis because of abnormal activation of cyclin B-Cdc2 and led to the activation of caspases 3 and 9 triggered by cytoplasmic release of cytochrome c. It belongs to the Ser/Thr family of protein kinases and NIM1 subfamily.

途径

p53 Pathway, Apoptosis, Cell Division Cycle, DNA Damage Repair

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