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- 抗原 See all STAT2 抗体
- STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This STAT2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- This Protein-A purified antibody is directed against human STAT2 protein. A BLAST analysis was used to suggest cross-reactivity with STAT2 protein from human, rat (73%) and mouse (76%), sources based on homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
- 产品特性
- STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. Our goal is to identify regions/motifs within the structural domains of STAT2 that not only are essential for the tyrosine phosphorylation of STAT2, but also regulate the antitumor effects of IFN-alpha. Collectively, the results of our studies will emphasize the physiological role of STAT2 in cancer. From a clinical viewpoint, cancer patients who may benefit the most from receiving IFN-alpha therapy can be selected based on their STAT2 function.
- 过滤
- Sterile filtered
- 免疫原
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This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues near the carboxy terminus of mouse STAT2 protein.
Immunogen Type: Peptide - 克隆位点
- 19G8-H2-H6
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product STAT2 Primary Antibody
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anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (AA 151-250) antibody
STAT2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (AA 616-849) antibodySTAT2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (AA 587-838) antibodySTAT2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (Tyr1221), (Tyr1222) antibodySTAT2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (AA 742-851) antibodySTAT2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 5G7 unconjugated
anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (C-Term) antibodySTAT2 适用: 人 WB, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (pTyr690) antibodySTAT2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) antibodySTAT2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal STAT2-2650 unconjugated
anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) antibodySTAT2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) (Internal Region), (pTyr690) antibodySTAT2 适用: 人, 大鼠, 小鼠, 马, Macaque, Pig, Vervet Monkey, Cow, 犬, Chimpanzee WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- This Protein-A purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 113 kDa in size corresponding to STAT2 protein by western blotting in the appropriate cell lysate or extract.
- 说明
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Gene Name: STAT2
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.0 mg/mL
- 缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
- 有效期
- 12 months
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- 抗原
- STAT2 (Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))
- 别名
- STAT2 (STAT2 产品)
- 别名
- wu:fj84d07 antibody, p113 antibody, stat2 antibody, 1600010G07Rik antibody, AW496480 antibody, ISGF-3 antibody, P113 antibody, STAT113 antibody, signal transducer and activator of transcription 2 antibody, AGAP000099-PA antibody, stat2 antibody, STAT2 antibody, Stat2 antibody
- 背景
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STAT2 is a member of the STAT family of transcription factors. Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex. This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription. Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation. IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment. Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. Our goal is to identify regions/motifs within the structural domains of STAT2 that not only are essential for the tyrosine phosphorylation of STAT2, but also regulate the antitumor effects of IFN-alpha. Collectively, the results of our studies will emphasize the physiological role of STAT2 in cancer. From a clinical viewpoint, cancer patients who may benefit the most from receiving IFN-alpha therapy can be selected based on their STAT2 function.
Synonyms: Stat2, Signal transducer and activator of transcription 2, p113 - 基因ID
- 6773, 4885615
- UniProt
- P52630
- 途径
- JAK/STAT Signaling, Hepatitis C, CXCR4-mediated Signaling Events
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