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HLA-DMB 抗体 (Middle Region)

HLA-DMB 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN952749
发货至: 中国
  • 抗原 See all HLA-DMB 抗体
    HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
    抗原表位
    • 12
    • 12
    • 7
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 103-133, Middle Region
    适用
    • 42
    • 1
    宿主
    • 39
    • 3
    克隆类型
    • 38
    • 4
    多克隆
    标记
    • 22
    • 4
    • 4
    • 4
    • 4
    • 4
    This HLA-DMB antibody is un-conjugated
    应用范围
    • 41
    • 31
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    特异性
    This antibody recognizes Human HLA class II DM beta / HLA-DMB (Center).
    纯化方法
    Protein A column, followed by peptide affinity purification
    免疫原
    KLH conjugated synthetic peptide between 103-133 amino acids from the Central region of human HLA class II DM beta / HLA-DMB
    亚型
    Ig Fraction
    Top Product
    Discover our top product HLA-DMB Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
    Abstract
    HLA-DMB 产品
    别名
    RING7 antibody, D6S221E antibody, RT1.DMb antibody, RT1.Mb antibody, MHC-DMB antibody, major histocompatibility complex, class II, DM beta antibody, RT1 class II, locus DMb antibody, HLA-DMB antibody, RT1-DMb antibody, PATR-DMB antibody
    背景
    HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.Synonyms: DMB, HLA class II histocompatibility antigen DM beta chain, MHC class II antigen DMB, RING7, Really interesting new gene 7 protein
    分子量
    28943 Da
    基因ID
    3109
    NCBI登录号
    NP_002109
    途径
    Cancer Immune Checkpoints
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