Caspase 12 抗体 (AA 201-300) (Alexa Fluor 488)
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- 抗原 See all Caspase 12 (CASP12) 抗体
- Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
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抗原表位
- AA 201-300
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适用
- 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Caspase 12 antibody is conjugated to Alexa Fluor 488
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from mouse Caspase 12
- 亚型
- IgG
- Top Product
- Discover our top product CASP12 Primary Antibody
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- 应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
- 别名
- Caspase 12 (CASP12 产品)
- 别名
- Caspase-12 antibody, CASP-12 antibody, CASP12P1 antibody, caspase 12 antibody, caspase 12 (gene/pseudogene) antibody, Casp12 antibody, CASP12 antibody
- 背景
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Synonyms: Caspase-12, CASP-12, Casp12
Background: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].
- 基因ID
- 12364
- UniProt
- O08736
- 途径
- Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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