DAB1 抗体 (pSer524) (Alexa Fluor 488)
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- 抗原 See all DAB1 抗体
- DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))
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抗原表位
- pSer524
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DAB1 antibody is conjugated to Alexa Fluor 488
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人, 小鼠
- 预测反应
- Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from mouse Dab1 around the phosphorylation site of Ser524
- 亚型
- IgG
- Top Product
- Discover our top product DAB1 Primary Antibody
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anti-Disabled Homolog 1 (Drosophila) (DAB1) (pTyr232) antibody
DAB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (AA 400-555), (C-Term) antibodyDAB1 适用: 小鼠, 兔 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (AA 400-555), (C-Term) antibodyDAB1 适用: 小鼠 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (pTyr232) antibodyDAB1 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (Ser296) antibodyDAB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (AA 1-185) antibodyDAB1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (pTyr198) antibodyDAB1 适用: 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) antibodyDAB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (Ser295) antibodyDAB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Disabled Homolog 1 (Drosophila) (DAB1) (AA 187-236) antibodyDAB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))
- 别名
- Dab1 (DAB1 产品)
- 别名
- AI956902 antibody, C630028C02Rik antibody, scm antibody, scr antibody, scrambler antibody, yot antibody, disabled-1 antibody, LOC100232823 antibody, si:dkey-242m13.1 antibody, DAB1 antibody, zgc:136547 antibody, DAB1, reelin adaptor protein antibody, disabled 1 antibody, disabled homolog 1 antibody, Dab, reelin signal transducer, homolog 1a (Drosophila) antibody, Dab, reelin signal transducer, homolog 1b (Drosophila) antibody, DAB1 antibody, Dab1 antibody, LOC100232823 antibody, dab1a antibody, dab1b antibody
- 背景
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Synonyms: Dab 1, Disabled homolog 1, Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot, Yotari.
Background: Disabled 1 (Dab1) is an 80 kDa protein that is encoded by the Disabled-1 gene locus which is mutated in scrambler and yotari mutant mice. Phenotypically, the mutation of this gene produces motor defects and ataxia, disruption of neuronal migration, and severe cerebellar hypoplasia. Dab1 is an intracellular adapter protein that functions in downstream signaling events initiated by the secreted protein reelin. Dab1 contains a phosphotyrosine binding (PTB) domain in the amino terminus. Tyrosine phosphorylation of Dab1 is increased by reelin binding to the Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) through stimulation of Src family kinases. Src family kinase and c-Abl activities are themselves then stimulated by binding to tyrosine phosphorylated Dab1. Dab1 also mediates activation of Akt (PKB) by reelin resulting in inhibition of glycogen synthase kinase 3 beta (GSK-3 beta) and decreased phosphorylation of the microtubule-associated protein, Tau. Dab1 serine 491 is phosphorylated in a Cdk5-dependent manner and regulates, likely indirectly, Reelin-induced signaling during neural cortex development.
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