The antibody detects endogenous levels of total g-Catenin protein.
纯化方法
Affinity purified
免疫原
Peptide sequence around AA 726-730 (I-D-T-Y-S) derived from Human g-Catenin Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton