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HRAS 抗体 (AA 101-177)

This 兔 多克隆 antibody specifically detects HRAS in WB 和 IHC (p). It exhibits reactivity toward 斑马鱼.
产品编号 ABIN7869890
发货至: 中国
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Quick Overview for HRAS 抗体 (AA 101-177) (ABIN7869890)

抗原

See all HRAS 抗体
HRAS (HRas proto-oncogene, GTPase (HRAS))

适用

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斑马鱼

宿主

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克隆类型

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多克隆

标记

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This HRAS antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

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    AA 101-177

    原理

    Zebrafish Hras Antibody / Isoforms a & b

    纯化方法

    Antigen affinity chromatography

    免疫原

    An E.coli-derived zebrafish Hrasa/b recombinant protein (amino acids K101-S177) was used as the immunogen for the Zebrafish Hras antibody. This antibody will detect the a and b isoforms.

    亚型

    Ig Fraction
  • 应用备注

    Optimal dilution of the Zebrafish Hras antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Lyophilized

    缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    4 °C,-20 °C

    储存方法

    After reconstitution, the Zebrafish Hras antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
  • 抗原

    HRAS (HRas proto-oncogene, GTPase (HRAS))

    别名

    Hras

    背景

    GTPase HRas, also known as transforming protein p21, is an enzyme that in humans is encoded by the HRAS gene. This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

    UniProt

    Q568K0

    途径

    p53 Pathway, MAPK Pathway, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling, BCR Signaling
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