FE65 抗体 (AA 201-300)
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- 抗原 See all FE65 (APBB1) 抗体
- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
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抗原表位
- AA 201-300
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适用
- 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FE65 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Human,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Fe65 protein
- 亚型
- IgG
- Top Product
- Discover our top product APBB1 Primary Antibody
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anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 21-56), (N-Term) antibody
APBB1 适用: 小鼠, 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 361-710) antibodyAPBB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 1-708) antibodyAPBB1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (C-Term) antibodyAPBB1 适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) antibodyAPBB1 适用: 大鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (pSer175) antibodyAPBB1 适用: 小鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (C-Term) antibodyVerified APBB1 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 197-246) antibodyAPBB1 适用: 小鼠, 人, 大鼠, 兔, 犬, Cow, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 359-708) antibodyAPBB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (N-Term) antibodyAPBB1 适用: 小鼠, 人, 大鼠, 兔, 犬, 马, Cow, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
- 别名
- FE65 (APBB1 产品)
- 别名
- FE65 antibody, MGC:9072 antibody, RIR antibody, apbb1 antibody, MGC80654 antibody, Fe65 antibody, Rir antibody, amyloid beta precursor protein binding family B member 1 antibody, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog antibody, amyloid beta (A4) precursor protein-binding, family B, member 1 antibody, APBB1 antibody, apbb1.L antibody, Apbb1 antibody
- 背景
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Synonyms: RIR, FE65, MGC:9072, Amyloid beta A4 precursor protein-binding family B member 1, Protein Fe65, APBB1
Background: Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
- 基因ID
- 322
- UniProt
- O00213
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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