FE65 抗体 (N-Term)
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- 抗原 See all FE65 (APBB1) 抗体
- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
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抗原表位
- N-Term
- 适用
- 小鼠, 人, 大鼠, 兔, 犬, 马, Cow, 豚鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FE65 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- DGPREHSKSA SLLFGMRNSA ASDEDSSWAT LSQGSPSYGS PEDTDSFWNP
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against Apbb1. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide corresponding to a region of Mouse
- Top Product
- Discover our top product APBB1 Primary Antibody
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anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 21-56), (N-Term) antibody
APBB1 适用: 小鼠, 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 201-300) antibodyAPBB1 适用: 小鼠, 大鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 361-710) antibodyAPBB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 1-708) antibodyAPBB1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (C-Term) antibodyAPBB1 适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) antibodyAPBB1 适用: 大鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (pSer175) antibodyAPBB1 适用: 小鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (C-Term) antibodyVerified APBB1 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 197-246) antibodyAPBB1 适用: 小鼠, 人, 大鼠, 兔, 犬, Cow, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 359-708) antibodyAPBB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 708 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
- 别名
- Apbb1 (APBB1 产品)
- 别名
- FE65 antibody, MGC:9072 antibody, RIR antibody, apbb1 antibody, MGC80654 antibody, Fe65 antibody, Rir antibody, amyloid beta precursor protein binding family B member 1 antibody, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog antibody, amyloid beta (A4) precursor protein-binding, family B, member 1 antibody, APBB1 antibody, apbb1.L antibody, Apbb1 antibody
- 背景
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Apbb1 is an adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain.Apbb1 plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. Apbb1 may act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Apbb1 is required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity.Apbb1 functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Apbb1 is associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
Alias Symbols: Fe65, Rir
Protein Interaction Partner: Rnf157, Enah, Prnp, APP, APLP2, APLP1, Evl,
Protein Size: 708 - 分子量
- 78 kDa
- 基因ID
- 11785
- NCBI登录号
- NM_009685, NP_033815
- UniProt
- Q9QXJ1
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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