FE65 产品
(Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
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The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012].
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Featured FE65 Categories
Recommended FE65 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (4)
Cat. No.
ABIN3043784
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN725075
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7144040
Quantity
100 μL
Datasheet
Datasheet
Recommended FE65 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345278
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345280
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345282
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our FE65 Products
: "Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation." in: Scientific reports, Vol. 5, pp. 11529, (2015) (PubMed).: "Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development." in: The EMBO journal, Vol. 25, Issue 2, pp. 420-31, (2006) (PubMed).
: "FE65 interaction with the ApoE receptor ApoEr2." in: The Journal of biological chemistry, Vol. 281, Issue 34, pp. 24521-30, (2006) (PubMed).
: "Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)." in: Molecular biology of the cell, Vol. 18, Issue 1, pp. 201-10, (2006) (PubMed).
: "The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 41182-8, (2003) (PubMed).
: "The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway." in: Biochemistry, Vol. 42, Issue 12, pp. 3627-34, (2003) (PubMed).
: "gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins." in: Biochemistry, Vol. 42, Issue 22, pp. 6664-73, (2003) (PubMed).
: "A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60." in: Science (New York, N.Y.), Vol. 293, Issue 5527, pp. 115-20, (2001) (PubMed).
Synonyms and alternative names related to FE65
amyloid beta precursor protein binding family B member 1 (APBB1), amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog (apbb1.L), amyloid beta (A4) precursor protein-binding, family B, member 1 (Apbb1), amyloid beta precursor protein binding family B member 1 (Apbb1), apbb1, FE65, Fe65, MGC80654, MGC:9072, RIR, RirProtein level used designations for FE65
- adaptor protein FE65a2
- amyloid beta A4 precursor protein-binding family B member 1
- stat-like protein
- amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
- amyloid beta A4 precursor protein-binding, family B, member 1
- amyloid beta precursor protein-binding B1
- amyloid beta A4 precursor protein-binding family B member 1-like
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