CHEK1 抗体
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北京 101111
Quick Overview for CHEK1 抗体 (ABIN7467901)
抗原
See all CHEK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Human Chk1
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交叉反应
- 人
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纯化方法
- Protein G affinity purified
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免疫原
- Full-length human Chk1
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亚型
- IgG1
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1XPBS ( pH 7), 20 % Glycerol, No Preservative
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储存液
- Without preservative
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储存条件
- 4 °C,-20 °C
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储存方法
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- CHEK1 (Checkpoint Kinase 1 (CHEK1))
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别名
- checkpoint kinase 1
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背景
- Checkpoint kinase 1 , CHK1,The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
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分子量
- 54 kDa
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基因ID
- 1111
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UniProt
- O14757
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途径
- p53 Pathway, Apoptosis, Cell Division Cycle, DNA Damage Repair
抗原
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