LATS1 抗体 (AA 1-280) (HRP)
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- 抗原 See all LATS1 抗体
- LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
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抗原表位
- AA 1-280
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LATS1 antibody is conjugated to HRP
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应用范围
- ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Serine/threonine-protein kinase LATS1 protein (1-280AA)
- 亚型
- IgG
- Top Product
- Discover our top product LATS1 Primary Antibody
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anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-280) antibody
LATS1 适用: 人 ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 521-620) antibodyLATS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A7 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (Internal Region) antibodyLATS1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (pThr1079) antibodyLATS1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-30), (N-Term) antibodyLATS1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB3029 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-30) antibodyLATS1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (pThr1041), (pThr1079) antibodyLATS1 适用: 人, 小鼠 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-1130) antibodyLATS1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 971-1020) antibodyLATS1 适用: 人, 小鼠, 大鼠, 犬, 马, 猴, 兔, 斑马鱼, Cow, Hamster, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (Middle Region) antibodyLATS1 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, 斑马鱼, Cow, Saccharomyces cerevisiae, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
- 别名
- LATS1 (LATS1 产品)
- 别名
- WARTS antibody, wts antibody, AW208599 antibody, Lats antibody, si:dkey-181i3.5 antibody, wu:fc19a11 antibody, zgc:123219 antibody, lats1 antibody, RGD1564085 antibody, warts antibody, large tumor suppressor kinase 1 antibody, large tumor suppressor antibody, large tumor suppressor kinase 1 S homeolog antibody, LATS1 antibody, Lats1 antibody, lats1 antibody, lats1.S antibody
- 背景
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Background: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Aliases: h-warts antibody, Large tumor suppressor homolog 1 antibody, LATS large tumor suppressor homolog 1 antibody, LATS1 antibody, LATS1_HUMAN antibody, Serine threonine protein kinase LATS1 antibody, Serine/threonine-protein kinase LATS1 antibody, WARTS antibody, WARTS protein kinase antibody, wts antibody
- UniProt
- O95835
- 途径
- Regulation of Actin Filament Polymerization, Maintenance of Protein Location
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