LATS1 抗体 (Internal Region)
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- 抗原 See all LATS1 抗体
- LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LATS1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- LATS1/2 Antibody detects endogenous levels of total LATS1/2.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human LATS1/2, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product LATS1 Primary Antibody
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anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-280) antibody
LATS1 适用: 人 ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 521-620) antibodyLATS1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A7 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (pThr1079) antibodyLATS1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-30), (N-Term) antibodyLATS1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB3029 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-30) antibodyLATS1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (pThr1041), (pThr1079) antibodyLATS1 适用: 人, 小鼠 IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 1-1130) antibodyLATS1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (AA 971-1020) antibodyLATS1 适用: 人, 小鼠, 大鼠, 犬, 马, 猴, Cow, 兔, 斑马鱼, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (Middle Region) antibodyLATS1 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 兔, 斑马鱼, Saccharomyces cerevisiae, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1) (N-Term) antibodyLATS1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- LATS1 (LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
- 别名
- LATS1 (LATS1 产品)
- 别名
- WARTS antibody, wts antibody, AW208599 antibody, Lats antibody, si:dkey-181i3.5 antibody, wu:fc19a11 antibody, zgc:123219 antibody, lats1 antibody, RGD1564085 antibody, warts antibody, large tumor suppressor kinase 1 antibody, large tumor suppressor antibody, large tumor suppressor kinase 1 S homeolog antibody, LATS1 antibody, Lats1 antibody, lats1 antibody, lats1.S antibody
- 背景
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Description: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).
Gene: LATS1
- 分子量
- 160 kDa
- 基因ID
- 9113
- UniProt
- O95835, Q9NRM7
- 途径
- Regulation of Actin Filament Polymerization, Maintenance of Protein Location
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