PIEZO1 抗体 (AA 2230-2420)
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- 抗原 See all PIEZO1 抗体
- PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))
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抗原表位
- AA 2230-2420
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIEZO1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Piezo-type mechanosensitive ion channel component 1 protein (2230-2420AA)
- 亚型
- IgG
- Top Product
- Discover our top product PIEZO1 Primary Antibody
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- 应用备注
- Recommended dilution: IHC:1:20-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))
- 别名
- PIEZO1 (PIEZO1 产品)
- 别名
- DHS antibody, FAM38A antibody, Mib antibody, 9630020g22 antibody, Fam38a antibody, mKIAA0233 antibody, piezo type mechanosensitive ion channel component 1 antibody, piezo-type mechanosensitive ion channel component 1 antibody, PIEZO1 antibody, Piezo1 antibody
- 背景
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Background: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).
Aliases: DHS antibody, Fam38a antibody, Family with sequence similarity 38 member A antibody, KIAA0233 antibody, Membrane protein induced by beta-amyloid treatment antibody, Mib antibody, PIEZ1_HUMAN antibody, Piezo-type mechanosensitive ion channel component 1 antibody, PIEZO1 antibody, Protein FAM38A antibody, Protein FAM38B antibody, Protein PIEZO1 antibody
- UniProt
- Q92508
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