PIEZO1 抗体 (Internal Region)
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- 抗原 See all PIEZO1 抗体
- PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIEZO1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Piezo1 Antibody detects endogenous levels of total Piezo1.
- 预测反应
- Pig,Bovine,Horse,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human Piezo1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PIEZO1 Primary Antibody
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anti-Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) (AA 2230-2420) antibody
PIEZO1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) (AA 2230-2420) antibodyPIEZO1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) antibodyPIEZO1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1) (AA 1863-1876) antibodyPIEZO1 适用: 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PIEZO1 (Piezo-Type Mechanosensitive Ion Channel Component 1 (PIEZO1))
- 别名
- PIEZO1 (PIEZO1 产品)
- 别名
- DHS antibody, FAM38A antibody, Mib antibody, 9630020g22 antibody, Fam38a antibody, mKIAA0233 antibody, piezo type mechanosensitive ion channel component 1 antibody, piezo-type mechanosensitive ion channel component 1 antibody, PIEZO1 antibody, Piezo1 antibody
- 背景
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Description: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).
Gene: PIEZO1
- 分子量
- 287 kDa
- 基因ID
- 9780
- UniProt
- Q92508
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