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PPM1A 抗体 (pSer375)

PPM1A 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN711761
发货至: 中国
  • 抗原 See all PPM1A 抗体
    PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
    抗原表位
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer375
    适用
    • 37
    • 19
    • 16
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 27
    • 10
    克隆类型
    • 28
    • 9
    多克隆
    标记
    • 25
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PPM1A antibody is un-conjugated
    应用范围
    • 30
    • 17
    • 8
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    预测反应
    Dog,Cow,Sheep,Guinea Pig
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic phosphopeptide derived from human PPM1A around the phosphorylation site of Ser375
    亚型
    IgG
    Top Product
    Discover our top product PPM1A Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
    别名
    PPM1A (PPM1A 产品)
    别名
    PP2C-ALPHA antibody, PP2CA antibody, PP2Calpha antibody, pp2ca1 antibody, ppp1r13b antibody, si:ch211-253p18.1 antibody, wu:fd42g12 antibody, zgc:153820 antibody, 2310003C21Rik antibody, 2900017D14Rik antibody, AI427932 antibody, AU017636 antibody, MMPa-2 antibody, MPPa-1 antibody, Pp2c1 antibody, pp2c-alpha antibody, pp2ca antibody, pp2calpha antibody, pp2ca2 antibody, protein phosphatase, Mg2+/Mn2+ dependent 1A antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Ab antibody, protein phosphatase 1A, magnesium dependent, alpha isoform antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1A antibody, protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Aa antibody, PPM1A antibody, ppm1ab antibody, Ppm1a antibody, ppm1a.L antibody, ppm1aa antibody
    背景

    Synonyms: PPM1Aphospho S375, Mpp alpha, PP2C alpha, PP2C-alpha, PP2CA, PPM 1A, PPM1A, PPM1A_HUMAN, PPPM1A, Protein phosphatase 1A formerly 2C magnesium dependent alpha isoform, Protein phosphatase 1A, Protein phosphatase 1A magnesium dependent alpha, Protein phosphatase 2C alpha, Protein phosphatase 2C alpha isoform, Protein phosphatase 2C isoform alpha, Protein phosphatase IA, Protein phosphatase 2C isoform alpha, IA antibody.

    Background: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

    基因ID
    5494
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