Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 抗体
(Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| PPM1A 抗体 (AA 202-382) | 人, 猴 | 小鼠 Monoclonal |
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| PPM1A 抗体 (AA 2-382) | 人 | 兔 Polyclonal |
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| PPM1A 抗体 (AA 1-382) | 人 | 小鼠 Monoclonal |
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| PPM1A 抗体 (AA 1-382) | 人 | 兔 Polyclonal |
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| PPM1A 抗体 (AA 1-383) | 人 | 小鼠 Monoclonal |
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| PPM1A 抗体 (AA 1-382) | 人 | 兔 Polyclonal |
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| Recombinant PPM1A 抗体 | 人 | 兔 Monoclonal |
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| PPM1A 抗体 (AA 1-382) | 人 | 小鼠 Polyclonal |
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| PPM1A 抗体 (N-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PPM1A 抗体 (AA 107-156) | 人, 小鼠, 大鼠, Cow, 兔, 犬, 豚鼠, 马, 小鸡, Pig, Bat, Hamster, 非洲爪蟾 | 兔 Polyclonal |
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| PPM1A 抗体 (C-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PPM1A 抗体 (AA 1-382) | 人 | 小鼠 Monoclonal |
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| PPM1A 抗体 (AA 1-382) | 人 | 小鼠 Monoclonal |
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| PPM1A 抗体 (pSer375) | 人 | 兔 Polyclonal |
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| PPM1A 抗体 (AA 2-382) | 人 | 兔 Polyclonal |
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| PPM1A 抗体 (AA 355-382) (APC) | 人 | 兔 Polyclonal |
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| PPM1A 抗体 (AA 355-382) (HRP) | 人 | 兔 Polyclonal |
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| PPM1A 抗体 (AA 1-324) | 人, 小鼠, 大鼠 | 小鼠 Monoclonal |
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| PPM1A 抗体 (AA 355-382) | 人 | 兔 Polyclonal |
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| PPM1A 抗体 (AA 355-382) (FITC) | 人 | 兔 Polyclonal |
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Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
2 references - 适用
- 人, 猴
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 7F12H6
- 标记
- unconjugated
- 抗体亚型
- IgG1
- 抗原表位
- AA 202-382
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- IF (Immunofluorescence: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 2-382
Primary Antibody
- ELISA (ELISA: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- PLA (Proximity Ligation Assay: 有验证图片)
- WB (Western Blotting: 有验证图片)
- ISt (Immunostaining: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 4E11
- 标记
- unconjugated
- 抗体亚型
- IgG2a
- 抗原表位
- AA 1-382
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 1-382
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- IHC (fp) (Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections): 有验证图片)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 4E11
- 标记
- unconjugated
- 抗体亚型
- IgG2a kappa
- 抗原表位
- AA 1-383
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 1-382
Primary Antibody
- WB (Western Blotting: 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Monoclonal
- 克隆
- 25GB1805
- 标记
- unconjugated
- 蛋白类型
- Recombinant Antibody
- 抗体亚型
- IgG
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1-382
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IF (Immunofluorescence: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- IF (Immunofluorescence: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- p6c7
- 标记
- unconjugated
- 抗体亚型
- IgG2b kappa
- 抗原表位
- AA 1-382
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- p6c7
- 标记
- unconjugated
- 抗体亚型
- IgG2b kappa
- 抗原表位
- AA 1-382
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- IHC (fro) (Immunohistochemistry (Frozen Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pSer375
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 2-382
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- APC
- 抗体亚型
- IgG
- 抗原表位
- AA 355-382
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- HRP
- 抗体亚型
- IgG
- 抗原表位
- AA 355-382
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 标记
- unconjugated
- 抗体亚型
- IgG1
- 抗原表位
- AA 1-324
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 355-382
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- FITC
- 抗体亚型
- IgG
- 抗原表位
- AA 355-382
Latest Publications for our Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 抗体
: "The intracellular protein phosphatase magnesium-dependent 1A negatively regulates osteoclast commitment." in: Arthritis & rheumatology (Hoboken, N.J.), (2019) (PubMed).
: "NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction." in: The Journal of biological chemistry, Vol. 292, Issue 19, pp. 7866-7887, (2017) (PubMed).
: "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." in: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).
: "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation." in: Cellular signalling, Vol. 21, Issue 1, pp. 95-102, (2008) (PubMed).
: "PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling." in: Cell, Vol. 125, Issue 5, pp. 915-28, (2006) (PubMed).
: "Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway." in: The Journal of biological chemistry, Vol. 281, Issue 48, pp. 36526-32, (2006) (PubMed).
: "Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes." in: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22715-26, (2004) (PubMed).
: "Cell cycle regulation and p53 activation by protein phosphatase 2C alpha." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 14299-305, (2003) (PubMed).
: "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 26, pp. 16006-11, (2003) (PubMed).
: "NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction." in: The Journal of biological chemistry, Vol. 292, Issue 19, pp. 7866-7887, (2017) (PubMed).
: "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." in: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).
: "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation." in: Cellular signalling, Vol. 21, Issue 1, pp. 95-102, (2008) (PubMed).
: "PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling." in: Cell, Vol. 125, Issue 5, pp. 915-28, (2006) (PubMed).
: "Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway." in: The Journal of biological chemistry, Vol. 281, Issue 48, pp. 36526-32, (2006) (PubMed).
: "Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes." in: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22715-26, (2004) (PubMed).
: "Cell cycle regulation and p53 activation by protein phosphatase 2C alpha." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 14299-305, (2003) (PubMed).
: "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 26, pp. 16006-11, (2003) (PubMed).
Aliases for Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A 抗体
protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A) 抗体protein phosphatase, Mg2+/Mn2+ dependent, 1Ab (ppm1ab) 抗体
protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a) 抗体
protein phosphatase, Mg2+/Mn2+ dependent, 1A (Ppm1a) 抗体
protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog (ppm1a.L) 抗体
protein phosphatase, Mg2+/Mn2+ dependent 1A (Ppm1a) 抗体
protein phosphatase, Mg2+/Mn2+ dependent, 1Aa (ppm1aa) 抗体
2310003C21Rik 抗体
2900017D14Rik 抗体
AI427932 抗体
AU017636 抗体
MMPa-2 抗体
MPPa-1 抗体
PP2C-ALPHA 抗体
pp2c-alpha 抗体
Pp2c1 抗体
PP2CA 抗体
pp2ca 抗体
pp2ca1 抗体
pp2ca2 抗体
PP2Calpha 抗体
pp2calpha 抗体
ppp1r13b 抗体
si:ch211-253p18.1 抗体
wu:fd42g12 抗体
zgc:153820 抗体
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