Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008].
Latest Publications for our Prothrombin Fragment 1+2,F1+2 抗体
Krenzlin, Gresser, Jussen, Riede, Taylor, Vogelaar, Ringel, Kempski, Alessandri: "The Cerebral Thrombin System Is Activated after Intracerebral Hemorrhage and Contributes to Secondary Lesion Growth and Poor Neurological Outcome in C57Bl/6 Mice." in: Journal of neurotrauma, Vol. 37, Issue 12, pp. 1481-1490, (2020) (PubMed).