CHEK1 抗体 (pSer317)
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- 抗原 See all CHEK1 抗体
- CHEK1 (Checkpoint Kinase 1 (CHEK1))
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抗原表位
- pSer317
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CHEK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 产品特性
- Phosphorylated antibody
- 纯化方法
- Affinity purification
- 免疫原
- A synthetic phosphorylated peptide around S317 of human CHEK1 (NP_001265.2).
- 亚型
- IgG
- Top Product
- Discover our top product CHEK1 Primary Antibody
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- 应用备注
- WB 1:500-1:2000 IF 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- CHEK1 (Checkpoint Kinase 1 (CHEK1))
- 别名
- CHEK1 (CHEK1 产品)
- 背景
- The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
- 分子量
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Observed_MW: 60 kDa
Calculated_MW: 43 kDa/50 kDa/54 kDa
- 基因ID
- 1111
- UniProt
- O14757
- 途径
- p53 Pathway, Apoptosis, Cell Division Cycle, DNA Damage Repair
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