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VISTA 抗体 (C-Term)

VISTA 适用: 人 ELISA, WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6992209
发货至: 中国
  • 抗原 See all VISTA 抗体
    VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))
    抗原表位
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    C-Term
    适用
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    宿主
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    克隆类型
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    多克隆
    标记
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    This VISTA antibody is un-conjugated
    应用范围
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    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    纯化方法
    VISTA Antibody is affinity chromatography purified via peptide column.
    免疫原
    VISTA antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human VISTA. The immunogen is located within the last 60 amino acids of VISTA.
    亚型
    IgG
    Top Product
    Discover our top product VISTA Primary Antibody
  • 应用备注
    VISTA antibody can be used for Immunohistochemistry at 2 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL. For Immunocytochemistry start at 1 μ,g/mL.

    Antibody validated: Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    VISTA Antibody is supplied in PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,4 °C
    储存方法
    VISTA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原
    VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))
    别名
    VISTA (VISTA 产品)
    别名
    MGC112715 antibody, MGC151567 antibody, B7-H5 antibody, B7H5 antibody, GI24 antibody, PP2135 antibody, SISP1 antibody, Dies1 antibody, VISTA antibody, V-set immunoregulatory receptor antibody, vsir antibody, Vsir antibody, VSIR antibody
    背景
    The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5).
    基因ID
    64115
    NCBI登录号
    NP_071436
    UniProt
    Q9H7M9
    途径
    Cancer Immune Checkpoints
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