VISTA 抗体
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- 抗原 See all VISTA 抗体
- VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This VISTA antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human SISP1/GI24
- 亚型
- IgG
- Top Product
- Discover our top product VISTA Primary Antibody
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- VISTA (V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA))
- 别名
- GI24 (VISTA 产品)
- 别名
- MGC112715 antibody, MGC151567 antibody, B7-H5 antibody, B7H5 antibody, GI24 antibody, PP2135 antibody, SISP1 antibody, Dies1 antibody, VISTA antibody, V-set immunoregulatory receptor antibody, vsir antibody, Vsir antibody, VSIR antibody
- 背景
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Synonyms: C10orf54, GI24_HUMAN, Platelet receptor Gi24, PP2135, SISP1, stress induced secreted protein 1, UNQ730/PRO1412.
Background: Platelet receptor GI24, also known as SISP1 or PP2135, is a 311 amino acid single-pass type I membrane protein that contains one Ig-like (immunoglobulin-like) domain. GI24 is thought to contribute to tumor-invasive growth in the collagen matrix and is encoded by a gene that maps to human chromosome 10q22.1. Chromosome 10 contains over 800 genes, 135 million nucleotides and comprises nearly 4.5 % of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious.
- 途径
- Cancer Immune Checkpoints
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