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CD40 抗体

CD40 适用: 小鼠 FACS, IF, Func 宿主: 大鼠 Monoclonal FGK45-5 unconjugated
产品编号 ABIN6933686
发货至: 中国
  • 抗原 See all CD40 抗体
    CD40
    适用
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    小鼠
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    大鼠
    克隆类型
    • 144
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    单克隆
    标记
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    This CD40 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)
    无交叉反应
    纯化方法
    Purified by Protein A/G
    免疫原
    Purified recombinant Mouse CD40 fusion protein
    克隆位点
    FGK45-5
    亚型
    IgG2a kappa
    Top Product
    Discover our top product CD40 Primary Antibody
  • 应用备注

    Positive Control: MPBMC's. Spleen, Thymus or Lymph Node.

    Known Application: Functional Studies (Order Antibody without BSA & Azide); Flow Cytometry (0.5-1ug/million cells in 0.1ml); Immunofluorescence (0.5-1ug/ml)Optimal dilution for a specific application should be determined.

    限制
    仅限研究用
  • 浓度
    200 μg/mL
    缓冲液
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-80 °C
    储存方法
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    有效期
    24 months
  • 抗原
    CD40
    别名
    CD40 (CD40 产品)
    别名
    Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody
    背景
    Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.
    分子量
    48kDa
    基因ID
    21939
    UniProt
    P27512
    途径
    NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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