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XRCC6/XRCC5 抗体

XRCC6/XRCC5 适用: 人 IF, FACS, ICC 宿主: 小鼠 Monoclonal KU729 unconjugated
产品编号 ABIN6938789
发货至: 中国
  • 抗原 See all XRCC6/XRCC5 products
    XRCC6/XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5/6 (XRCC6/XRCC5))
    适用
    • 5
    • 4
    宿主
    • 4
    • 1
    小鼠
    克隆类型
    • 4
    • 1
    单克隆
    标记
    • 3
    • 1
    • 1
    This XRCC6/XRCC5 antibody is un-conjugated
    应用范围
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    特异性
    Recognizes a dimer of two proteins of 70 kDa and ~80 kDa, identified as two subunits of Ku. This MAb recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460 kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
    无交叉反应
    小鸡, 小鼠, 大鼠
    交叉反应 (详细)
    Human. Primates. Does not react with mouse, rat and chicken.
    纯化方法
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    免疫原
    Nuclear extract of human HL-60 cells
    克隆位点
    KU729
    亚型
    IgG1 kappa
  • 应用备注

    Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), ,Immunocytochemistry (Acetone-fixed cells) (0.5-1.0 μg/mL for 30 minutes at RT),Optimal dilution for a specific application should be determined.

    Positive_Control: K562, HL-60, HEp-2 or HeLa cells.

    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    储存液
    Azide free
    储存条件
    -20 °C,-80 °C
    储存方法
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    有效期
    24 months
  • 抗原
    XRCC6/XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5/6 (XRCC6/XRCC5))
    别名
    XRCC6 (p70) & XRCC5 (p80) (XRCC6/XRCC5 产品)
    背景
    70 kDa / 80 kDa subunit of Ku antigen, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, G22P1, Lupus Ku autoantigen protein p70, ML8, Thyroid autoantigen 70kD (Ku antigen), Thyroid-lupus autoantigen (TLAA), X-ray repair cross-complementing protein 6 (XRCC6), ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, CTCBF, KARP1, KUB2, Lupus Ku autoantigen protein p86, Nuclear factor IV (NFIV), X-ray repair cross-complementing protein 5 (XRCC5),Ku (p70/p80) (Nuclear Marker)
    Cellular localisation: Nuclear
    分子量
    70kDa & 80kDa
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